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EP 3 565 600 A1

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(43) Date of publication: 13.11.2019 Bulletin 2019/46 (21) Application number: 17888222.1 (22) Date of filing: 28.12.2017

(51) International Patent Classification (IPC):  A61K 47/10(2017.01) A61K 47/26(2006.01) A61K 47/14(2017.01) C07C 31/08(2006.01) (86) International application number: PCT/US2017/068777 (87) International publication number: WO 2018/126049 (05.07.2018 Gazette 2018/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD TN (30) Priority: 30.12.2016 US 201662440658 P 29.06.2017 WO PCT/US2017/039968 29.06.2017 US 201715637401 29.06.2017 CA 2972296 (71) Applicants: Durect Corporation Cupertino, CA 95014-4166 (US) Santen Pharmaceutical Co., Ltd. Higashiyodogawa-ku Osaka-shi Osaka 533-8651 (JP)

(72) Inventors: TAMRAZ, Wilma San Jose California 95120 (US) SU, Huey-Ching Lin San Jose California 95120 (US) LIN, WeiQi Emerald Hills California 94062 (US) YAMADA, Kazuhito Ikoma-shi Nara 630-0101 (JP) MATSUMOTO, Naoki Ikoma-shi Nara 630-0101 (JP) MUDUMBA, Sreenivasu Emeryville California 94608 (US) OKABE, Komei Ikoma-shi Nara 630-0101 (JP) (74) Representative: J A Kemp LLP  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)