(19)
(11) EP 3 569 697 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
27.04.2022 Bulletin 2022/17

(45) Mention of the grant of the patent:
05.01.2022 Bulletin 2022/01

(21) Application number: 19169309.2

(22) Date of filing: 05.06.2015
(51) International Patent Classification (IPC): 
C12N 5/074(2010.01)
A61K 35/12(2015.01)
 C12N 5/0775(2010.01)
(52) Cooperative Patent Classification (CPC):
A61K 2035/124; C12N 2320/30; C12N 5/0663; A61K 35/28; A61P 15/00

(54)

STEM CELL THERAPY IN ENDOMETRIAL PATHOLOGIES

STAMMZELLENTHERAPIE BEI ENDOMETRIUMPATHOLOGIEN

THÉRAPIE DE CELLULES SOUCHES DANS DES PATHOLOGIES ENDOMÉTRIALES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 17.06.2014 US 201462013121 P

(43) Date of publication of application:
20.11.2019 Bulletin 2019/47

(60) Divisional application:
22150013.5

(62) Application number of the earlier application in accordance with Art. 76 EPC:
15781411.2 / 3158057

(73) Proprietor: ASHERMAN THERAPY, S.L.
46980 Paterna, Valencia (ES)

(72) Inventors:
  • SIMON, Carlos
    46980 Valencia (ES)
  • SANTAMARIA, Javier
    46980 Valencia (ES)
  • PELLICER, Antonio
    46026 Valencia (ES)
  • CERVELLO, Irene
    46026 Valencia (ES)

(74) Representative: ABG Intellectual Property Law, S.L. 
Avenida de Burgos, 16D Edificio Euromor
28036 Madrid
28036 Madrid (ES)


(56) References cited: : 
   
  • NAGORI CHAITANYA B ET AL: "Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome.", JOURNAL OF HUMAN REPRODUCTIVE SCIENCES JAN 2011, vol. 4, no. 1, January 2011 (2011-01), pages 43-48, XP009187132, ISSN: 1998-4766
  • GARGETT CAROLINE E ET AL: "Generating receptive endometrium in Asherman's syndrome.", JOURNAL OF HUMAN REPRODUCTIVE SCIENCES JAN 2011, vol. 4, no. 1, January 2011 (2011-01), pages 49-52, XP009187143, ISSN: 1998-4766
  • FERYAL ALAWADHI ET AL: "Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome", PLOS ONE, vol. 9, no. 5, 12 May 2014 (2014-05-12), page e96662, XP055227054, DOI: 10.1371/journal.pone.0096662
  • MA N ET AL: "Intramyocardial delivery of human CD133+ cells in a SCID mouse cryoinjury model: Bone marrow vs. cord blood-derived cells", CARDIOVASCULAR RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 71, no. 1, 1 July 2006 (2006-07-01), pages 158-169, XP025011520, ISSN: 0008-6363, DOI: 10.1016/J.CARDIORES.2006.03.020 [retrieved on 2006-07-01]
  • IRENE CERVELLÓ ET AL: "Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome", FERTILITY AND STERILITY., 15 September 2015 (2015-09-15), XP055227050, USA ISSN: 0015-0282, DOI: 10.1016/j.fertnstert.2015.08.032
  • ZHAO JING ET AL: "Uterine infusion with bone marrow mesenchymal stem cells improves endometrium thickness in a rat model of thin endometrium.", REPRODUCTIVE SCIENCES (THOUSAND OAKS, CALIF.) FEB 2015, vol. 22, no. 2, February 2015 (2015-02), pages 181-188, XP009187112, ISSN: 1933-7205
  • CERVELLÓ IRENE ET AL: "Cell Therapy and Tissue Engineering from and toward the Uterus", SEMINARS IN REPRODUCTIVE MEDICINE,, vol. 33, no. 5, 1 September 2015 (2015-09-01), pages 366-371, XP009187109,
  • XAVIER SANTAMARIA ET AL: "Uterine stem cells: from basic research to advanced cell therapies", HUMAN REPRODUCTION UPDATE, vol. 24, no. 6, 15 September 2018 (2018-09-15), pages 673-693, XP055609487, ISSN: 1355-4786, DOI: 10.1093/humupd/dmy028
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).