| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
20.01.2017 US 201762448921 P
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| (43) |
Date of publication of application: |
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27.11.2019 Bulletin 2019/48 |
| (73) |
Proprietors: |
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- VERACYTE SD, Inc.
San Diego, CA 92121 (US)
- THE UNIVERSITY OF BRITISH COLUMBIA
Vancouver, BC V6T 1Z4 (CA)
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| (72) |
Inventors: |
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- DAVICIONI, Elai
La Jolla, California 92037 (US)
- ASHAB, Hussam Al-Deen
North York, Ontario M2K 1E8 (CA)
- ERHO, Nicholas
Vancouver, British Columbia V6B 6H4 (CA)
- BLACK, Peter
Vancouver, British Columbia V6N 2W6 (CA)
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| (74) |
Representative: Cabinet Becker et Associés |
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25, rue Louis le Grand 75002 Paris 75002 Paris (FR) |
| (56) |
References cited: :
WO-A1-2014/085666 WO-A1-2015/073949
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WO-A1-2014/085666
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- MARGARET A. KNOWLES ET AL: "Molecular biology of bladder cancer: new insights into
pathogenesis and clinical diversity", NATURE REVIEWS CANCER, vol. 15, no. 1, 23 December
2014 (2014-12-23), pages 25-41, XP055269452, London ISSN: 1474-175X, DOI: 10.1038/nrc3817
- WOONYOUNG CHOI ET AL: "Intrinsic basal and luminal subtypes of muscle-invasive bladder
cancer", NATURE REVIEWS. UROLOGY, vol. 11, no. 7, 24 June 2014 (2014-06-24), pages
400-410, XP055269413, US ISSN: 1759-4812, DOI: 10.1038/nrurol.2014.129
- HA KEVIN CH ET AL: "Comparison of Affymetrix Gene Array with the Exon Array shows
potential application for detection of transcript isoform variation", BMC GENOMICS,
BIOMED CENTRAL, vol. 10, no. 1, 12 November 2009 (2009-11-12), page 519, XP021062207,
ISSN: 1471-2164, DOI: 10.1186/1471-2164-10-519
- DAMRAUER et al.: "Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks
of breast cancer biology", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE
UNITED STATES OF AMERICA (PNAS), vol. 111, no. 8, 25 February 2014 (2014-02-25), pages
3110-3115, XP055269416, ISSN: 0027-8424
- MCCONKEY et al.: "A prognostic gene expression signature in the molecular classification
of chemotherapy-naïve urothelial cancer is predictive of clinical outcomes from neoadjuvant
chemotherapy: A phase 2 trial of dose-dense methotrexate, vinblastine, doxorubicin,
and cisplatin with bevacizumab in urothelial cancer", EUROPEAN UROLOGY, vol. 69, no.
5, May 2016 (2016-05), pages 855-862, XP029501687, ISSN: 0302-2838
- SEILER et al.: "Impact of molecular subtypes in muscle-invasive bladder cancer on
predicting response and survival after neoadjuvant chemotherapy", EUROPEAN UROLOGY,
vol. 72, no. 4, October 2017 (2017-10), pages 544-554, XP085198426, ISSN: 0302-2838
- CHOI et al.: "Identification of distinct basal and luminal subtypes of muscle-invasive
bladder cancer with different sensitivities to frontline chemotherapy", CANCER CELL,
vol. 25, no. 2, 10 February 2014 (2014-02-10), pages 152-165, XP028610273, ISSN: 1535-6108
- BITON et al.: "Independent component analysis uncovers the landscape of the bladder
tumor transcriptome and reveals insights into luminal and basal subtypes", CELL REPORTS,
vol. 9, no. 4, 20 November 2014 (2014-11-20), pages 1235-1245, XP055269445, ISSN:
2211-1247
- MCCONKEY et al.: "Therapeutic opportunities in the intrinsic subtypes of muscle-invasive
bladder cancer", HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA, vol. 29, no. 2, April
2015 (2015-04), pages 377-94, XP009516102, ISSN: 0889-8588, DOI: 10.1016/j.hoc.2014.11.003
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