(19)
(11) EP 3 574 900 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
published in accordance with Art. 153(4) EPC

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
09.06.2021 Bulletin 2021/23

(43) Date of publication:
04.12.2019 Bulletin 2019/49

(21) Application number: 18760546.4

(22) Date of filing: 22.02.2018
(51) International Patent Classification (IPC): 
A61K 31/438(2006.01)
A61K 9/48(2006.01)
A61K 9/02(2006.01)
A61P 31/04(2006.01)
A61K 47/54(2017.01)
A61K 47/10(2017.01)
 A61K 9/70(2006.01)
A61K 9/20(2006.01)
A61K 9/00(2006.01)
A61P 15/02(2006.01)
A61K 9/06(2006.01)
A61K 47/32(2006.01)
(86) International application number:
PCT/CN2018/076969
(87) International publication number:
WO 2018/157750 (07.09.2018 Gazette 2018/36)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 28.02.2017 CN 201710109978

(71) Applicant: Tennor Therapeutics Limited
Suzhou, Jiangsu 215123 (CN)

(72) Inventors:
  • MA, Zhenkun
    Suzhou Jiangsu 215123 (CN)
  • YUAN, Ying
    Suzhou Jiangsu 215123 (CN)
  • LIU, Yu
    Suzhou Jiangsu 215123 (CN)
  • WANG, Xiaomei
    Suzhou Jiangsu 215123 (CN)

(74) Representative: Gong, Jinping 
CocreateIP Eggenfeldenerstraße 56
81929 München
81929 München (DE)


(56) References cited: : 
   
       


    (54) NEW APPLICATIONS OF RIFAMYCIN-NITROIMIDAZOLE COUPLING MOLECULES


    (57) The present invention discloses a use of a rifamycin-nitroimidazole conjugate molecule shown in formula I against anaerobic bacteria. The rifamycin-nitroimidazole conjugate molecule shown in formula I of the present invention has broad-spectrum antibacterial activity against anaerobic bacteria, including activity against most pathogenic bacteria associated with bacterial vaginosis, in vitro antibacterial activity stronger than that of drugs against bacterial vaginosis such as metronidazole and clindamycin, and potential use in prevention and treatment of bacterial vaginosis or other related diseases caused by anaerobic bacteria.