(19)

(11)

EP 3 583 090 A1

(12)

(43) Date of publication: 25.12.2019 Bulletin 2019/52 (21) Application number: 18753595.0 (22) Date of filing: 13.02.2018

(51) International Patent Classification (IPC):  C07D 207/14(2006.01) A61K 31/485(2006.01) A61K 31/40(2006.01) A61P 25/00(2006.01) (86) International application number: PCT/US2018/018074 (87) International publication number: WO 2018/152134 (23.08.2018 Gazette 2018/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD TN (30) Priority: 14.02.2017 US 201762458731 P (71) Applicant: Research Triangle Institute Research Triangle Park, NC 27709 (US)	(72) Inventors: ZHANG, Yanan Apex, NC 27502 (US) NGUYEN, Thuy Morrisville, NC 27560 (US) (74) Representative: Murgitroyd & Company  Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)