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<ep-patent-document id="EP18708920B8W1" file="EP18708920W1B8.xml" lang="en" country="EP" doc-number="3583209" kind="B8" correction-code="W1" date-publ="20250226" status="c" dtd-version="ep-patent-document-v1-7">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>0009290-CORR01</B007EP><B050EP><B051EP>en</B051EP><B052EP>The complete document including Reference Table(s) and the Sequence Listing(s) can be downloaded from the EPO website</B052EP></B050EP></eptags></B000><B100><B110>3583209</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20250226</date></B140><B150><B151>W1</B151><B153>72</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>18708920.6</B210><B220><date>20180214</date></B220><B240><B241><date>20190913</date></B241><B242><date>20210521</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>201700016321</B310><B320><date>20170214</date></B320><B330><ctry>IT</ctry></B330></B300><B400><B405><date>20250226</date><bnum>202509</bnum></B405><B430><date>20191225</date><bnum>201952</bnum></B430><B450><date>20241204</date><bnum>202449</bnum></B450><B452EP><date>20240722</date></B452EP><B480><date>20250226</date><bnum>202509</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C12N   9/22        20060101AFI20180824BHEP        </text></classification-ipcr></B510EP><B520EP><classifications-cpc><classification-cpc sequence="1"><text>C12N   9/22        20130101 FI20171025BHEP        </text></classification-cpc><classification-cpc sequence="2"><text>C12Y 301/00        20130101 LI20171025BHEP        </text></classification-cpc><classification-cpc sequence="3"><text>C07K2319/71        20130101 LA20171025BHEP        </text></classification-cpc><classification-cpc sequence="4"><text>C07K2319/80        20130101 LA20171025BHEP        </text></classification-cpc></classifications-cpc></B520EP><B540><B541>de</B541><B542>HIGH-FIDELITY-CAS9-VARIANTEN UND ANWENDUNGEN DAVON</B542><B541>en</B541><B542>HIGH-FIDELITY CAS9 VARIANTS AND APPLICATIONS THEREOF</B542><B541>fr</B541><B542>VARIANTS DE CAS9 HAUTE FIDÉLITÉ ET LEURS APPLICATIONS</B542></B540><B560><B561><text>WO-A1-2016/164797</text></B561><B561><text>WO-A1-2016/205613</text></B561><B561><text>US-B1- 9 512 446</text></B561><B562><text>CASINI A ET AL: "Identification of high-fidelity Cas9 variants using a yeast-based screening", HUMAN GENE THERAPY, vol. 27, no. 11, 18 October 2016 (2016-10-18) - 21 October 2016 (2016-10-21), &amp; CONFERENCE ON CHANGING THE FACE OF MODERN MEDICINE - STEM CELLS AND GENE THERAPY; FLORENCE, ITALY, pages A41</text></B562><B562><text>IAN M SLAYMAKER ET AL: "Rationally engineered Cas9 nucleases with improved specificity", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, vol. 351, no. 6268, 1 January 2016 (2016-01-01), pages 84 - 88, XP002757561, ISSN: 0036-8075, [retrieved on 20151201], DOI: 10.1126/SCIENCE.AAD5227</text></B562><B562><text>BENJAMIN P. KLEINSTIVER ET AL: "High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects", NATURE, vol. 529, no. 7587, 6 January 2016 (2016-01-06), pages 490 - 495, XP055303390, ISSN: 0028-0836, DOI: 10.1038/nature16526</text></B562><B562><text>M. JINEK ET AL: "Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation", SCIENCE, vol. 343, no. 6176, 14 March 2014 (2014-03-14), pages 1247997 - 1247997, XP055149157, ISSN: 0036-8075, DOI: 10.1126/science.1247997</text></B562></B560></B500><B700><B720><B721><snm>CERESETO, Anna</snm><adr><str>c/o UNIVERSITA' DEGLI STUDI DI TRENTO
Via Calepina 14</str><city>38122 Trento</city><ctry>IT</ctry></adr></B721><B721><snm>CASINI, Antonio</snm><adr><str>c/o UNIVERSITA' DEGLI STUDI DI TRENTO
Via Calepina 14</str><city>38122 Trento</city><ctry>IT</ctry></adr></B721><B721><snm>PETRIS, Gianluca</snm><adr><str>c/o UNIVERSITA' DEGLI STUDI DI TRENTO
Via Calepina 14</str><city>38122 Trento</city><ctry>IT</ctry></adr></B721><B721><snm>INGA, Alberto</snm><adr><str>c/o UNIVERSITA' DEGLI STUDI DI TRENTO
Via Calepina 14</str><city>38122 Trento</city><ctry>IT</ctry></adr></B721><B721><snm>OLIVIERI, Michele</snm><adr><str>c/o UNIVERSITA' DEGLI STUDI DI TRENTO
Via Calepina 14</str><city>38122 Trento</city><ctry>IT</ctry></adr></B721></B720><B730><B731><snm>Università Degli Studi Di Trento</snm><iid>101587045</iid><irf>P019361EP-01/ca</irf><adr><str>Via Calepina 14</str><city>38122 Trento</city><ctry>IT</ctry></adr></B731></B730><B740><B741><snm>Valenza, Silvia</snm><sfx>et al</sfx><iid>101213609</iid><adr><str>Notarbartolo &amp; Gervasi S.p.A.
Viale Achille Papa, 30</str><city>20149 Milano</city><ctry>IT</ctry></adr></B741></B740></B700><B800><B840><ctry>AL</ctry><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IS</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LT</ctry><ctry>LU</ctry><ctry>LV</ctry><ctry>MC</ctry><ctry>MK</ctry><ctry>MT</ctry><ctry>NL</ctry><ctry>NO</ctry><ctry>PL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>RS</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>SM</ctry><ctry>TR</ctry></B840><B860><B861><dnum><anum>EP2018053717</anum></dnum><date>20180214</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2018149888</pnum></dnum><date>20180823</date><bnum>201834</bnum></B871></B870></B800><B7000><B7001><date>20241231</date></B7001></B7000></SDOBI>
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