(19)
(11) EP 3 587 392 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
27.05.2020 Bulletin 2020/22

(43) Date of publication:
01.01.2020 Bulletin 2020/01

(21) Application number: 19190425.9

(22) Date of filing: 09.10.2015
(51) International Patent Classification (IPC): 
C07C 217/74(2006.01)
A61K 9/107(2006.01)
A61P 27/02(2006.01)
A61K 31/12(2006.01)
A61K 31/5575(2006.01)
 A61K 9/51(2006.01)
A61K 31/357(2006.01)
A61K 9/00(2006.01)
A61K 31/44(2006.01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Validation States:
MA

(30) Priority: 09.10.2014 IT FI20140230

(62) Application number of the earlier application in accordance with Art. 76 EPC:
15797412.2 / 3203989

(71) Applicant: Distretto Tecnologico Sicilia Micro e Nano Sistemi S.C.A.R.L.
95121 Catania (IT)

(72) Inventors:
  • BLANCO, Anna Rita
    95024 ACIREALE (IT)
  • BONDI, Maria Luisa
    90019 TRABIA (IT)
  • CAVALLARO, Gennara
    90122 PALERMO (IT)
  • CONSOLI, Grazia Maria Letizia
    95027 San Gregorio di Catania (IT)
  • CRAPARO, Emanuela Fabiola
    90123 PALERMO (IT)
  • GIAMMONA, Gaetano
    90146 PALERMO (IT)
  • LICCIARDI, Mariano
    90129 PALERMO (IT)
  • PITARRESI, Giovanna
    90123 PALERMO (IT)
  • GRANATA, Giuseppe
    95024 ACIREALE (IT)
  • SALADINO, Patrizia
    91029 SANTA NINFA (IT)
  • LA MARCA, Clara
    92024 CANICATTI (IT)
  • DEIDDA, Irene
    90125 PALERMO (IT)
  • PAPASERGI, Salvatore
    89029 TAURIANOVA (IT)
  • GUARNERI, Patrizia
    90144 PALERMO (IT)
  • CUZZOCREA, Salvatore
    98167 MESSINA (IT)
  • ESPOSITO, Emanuela
    80125 NAPOLI (IT)
  • VIOLA, Santa
    95047 PATERNO' (IT)

(74) Representative: Coppo, Alessandro et al
Notarbartolo & Gervasi S.p.A. Corso di Porta Vittoria, 9
20122 Milano
20122 Milano (IT)

 
Remarks:
This application was filed on 07-08-2019 as a divisional application to the application mentioned under INID code 62.
 


(54) NANOSTRUCTURED FORMULATIONS FOR THE DELIVERY OF SILIBININ AND OTHER ACTIVE INGREDIENTS FOR TREATING OCULAR DISEASES


(57) Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.