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EP 3 589 284 A1

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(43) Date of publication: 08.01.2020 Bulletin 2020/02 (21) Application number: 18760857.5 (22) Date of filing: 28.02.2018

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/506(2006.01) A61K 31/505(2006.01) (86) International application number: PCT/US2018/020335 (87) International publication number: WO 2018/160774 (07.09.2018 Gazette 2018/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD TN (30) Priority: 28.02.2017 US 201762464675 P 16.03.2017 US 201762472468 P (71) Applicants: The General Hospital Corporation Boston, Massachusetts 02114 (US) Dana-Farber Cancer Institute, Inc. Boston, MA 02215 (US)

(72) Inventors: MURAKAMI, Ryo Tokyo 112-0011 (JP) FISHER, David, E. Newton, MA 02459 (US) MUJAHID, Nisma Spencerport, NY 14559 (US) GRAY, Nathanael, S. Boston, MA 02130 (US) LIANG, Yanke Belmont, MA 02478 (US) CHOI, Hwan Geun Chestnut Hill, MA 02467 (US) (74) Representative: Crooks, Elizabeth Caroline et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)