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(11)

EP 3 589 315 A1

(12)

(43) Date of publication: 08.01.2020 Bulletin 2020/02 (21) Application number: 18760878.1 (22) Date of filing: 02.03.2018

(51) International Patent Classification (IPC):  A61K 39/21(2006.01) A61K 38/16(2006.01) C12N 15/09(2006.01) C07K 14/16(2006.01) A61K 39/39(2006.01) C12N 7/04(2006.01) C12N 15/10(2006.01) (86) International application number: PCT/US2018/020788 (87) International publication number: WO 2018/161049 (07.09.2018 Gazette 2018/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.03.2017 WO PCT/US2017/020823 31.01.2018 US 201862624620 P (71) Applicant: Duke University Durham, NC 27705 (US)	(72) Inventors: HAYNES, Barton, F. Durham, NC 27705 (US) SAUNDERS, Kevin, O. Durham, NC 27705 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)