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EP 3 589 646 A1

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(43) Date of publication: 08.01.2020 Bulletin 2020/02 (21) Application number: 18760420.2 (22) Date of filing: 02.03.2018

(51) International Patent Classification (IPC):  C07K 14/505(2006.01) C07K 14/725(2006.01) C07K 16/28(2006.01) C07K 16/46(2006.01) A61K 38/43(2006.01) C07K 14/705(2006.01) C07K 16/18(2006.01) C07K 16/30(2006.01) A61K 38/17(2006.01) A61K 35/14(2015.01) (86) International application number: PCT/US2018/020741 (87) International publication number: WO 2018/161017 (07.09.2018 Gazette 2018/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.03.2017 US 201762466601 P 11.04.2017 US 201762484052 P (71) Applicant: Obsidian Therapeutics, Inc. Cambridge, MA 02138 (US)

(72) Inventors: SURI, Vipin Belmont, Massachusetts 02478 (US) BRISKIN, Michael Joseph Lexington, Massachusetts 02421 (US) DOLINSKI, Brian Cambridge, Massachusetts 02138 (US) ELPEK, Kutlu Goksu Arlington, Massachusetts 02476 (US) LI, Dan Jun Cambridge, Massachusetts 02138 (US) HELLER, Scott Francis Stoughton, Massachusetts 02072 (US) OLS, Michelle Lynn Northborough, Massachusetts 01532 (US) SUN, Dexue Cambridge, Massachusetts 02138 (US) KOSMIDER, Nicole Cambridge, Massachusetts 02138 (US) KULKARNI, Abhishek Brookline, Massachusetts 02445 (US) BALAKRISHNAN, Vijaya Groton, Massachusetts 01450 (US) EZELL, Tucker Cambridge, Massachusetts 02138 (US) (74) Representative: Adams, Harvey Vaughan John  Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA London WC1B 5HA (GB)