(19)

(11)

EP 3 596 076 A1

(12)

(43) Date of publication: 22.01.2020 Bulletin 2020/04 (21) Application number: 18713818.5 (22) Date of filing: 15.03.2018

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61P 35/00(2006.01) A61K 31/437(2006.01) (86) International application number: PCT/EP2018/056516 (87) International publication number: WO 2018/167203 (20.09.2018 Gazette 2018/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.03.2017 US 201762472080 P (71) Applicant: Astrazeneca AB 151 85 Södertälje (SE)	(72) Inventors: PIKE, Kurt, Gordon Cambridge CB4 0WG (GB) BARLAAM, Bernard, Christophe Cambridge Cambridgeshire CB4 0WG (GB) (74) Representative: AstraZeneca  Milstein Building Granta Park Cambridge CB21 6GH Cambridge CB21 6GH (GB)