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EP 3 601 541 A1

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(43) Date of publication: 05.02.2020 Bulletin 2020/06 (21) Application number: 17902030.0 (22) Date of filing: 22.03.2017

(51) International Patent Classification (IPC):  C12N 5/10(2006.01) A01K 67/00(2006.01) A61P 21/00(2006.01) C12N 15/12(2006.01) A61K 35/30(2015.01) (86) International application number: PCT/CN2017/077708 (87) International publication number: WO 2018/170794 (27.09.2018 Gazette 2018/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (71) Applicant: Tsinghua University Beijing 100084 (CN)	(72) Inventors: ZHANG, Xue Beijing 100084 (CN) JIA, Yichang Beijing 100084 (CN) (74) Representative: karo IP  Kahlhöfer Rößler Kreuels Patentanwälte PartG mbB Postfach 32 01 02 40416 Düsseldorf 40416 Düsseldorf (DE)