(19)
(11) EP 3 601 596 A1

(12)

(43) Date of publication:
05.02.2020 Bulletin 2020/06

(21) Application number: 18771954.7

(22) Date of filing: 15.03.2018
(51) International Patent Classification (IPC): 
C12Q 1/68(2018.01)
(86) International application number:
PCT/US2018/022664
(87) International publication number:
WO 2018/175202 (27.09.2018 Gazette 2018/39)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 24.03.2017 US 201762476234 P

(71) Applicant: The Johns Hopkins University
Baltimore, MD 21218 (US)

(72) Inventors:
  • VOGELSTEIN, Bert
    Baltimore, Maryland 21208 (US)
  • KINZLER, Kenneth W.
    Baltimore, Maryland 21230 (US)
  • PAPADOPOULOS, Nickolas
    Towson, Maryland 21204 (US)
  • MATTOX, Austin
    Baltimore, Maryland 21218 (US)
  • YEGNASUBRAMANIAN, Srinivasan
    Baltimore, Maryland 21218 (US)
  • NELSON, William G.
    Baltimore, Maryland 21205 (US)

(74) Representative: D Young & Co LLP 
120 Holborn
London EC1N 2DY
London EC1N 2DY (GB)

   


(54) STRAND-SPECIFIC DETECTION OF BISULFITE-CONVERTED DUPLEXES