(19)
(11) EP 3 603 676 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
25.03.2020 Bulletin 2020/13

(43) Date of publication:
05.02.2020 Bulletin 2020/06

(21) Application number: 19178288.7

(22) Date of filing: 07.04.2006
(27) Previously filed application:
 07.04.2006 EP 18166210
(51) International Patent Classification (IPC): 
A61K 48/00(2006.01)
A61K 35/76(2015.01)
 C12N 15/864(2006.01)
C12N 7/00(2006.01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 07.04.2005 US 669083 P
04.11.2005 US 733497 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
18166210.7 / 3409296
16154948.0 / 3085389
06749685.1 / 1866422

(71) Applicant: The Trustees of the University of Pennsylvania
Philadelphia, PA 19104-3242 (US)

(72) Inventors:
  • VANDENBERGHE, Luk
    Philadelphia, PA 19146 (US)
  • GAO, Guangping
    Rosemont, PA 19010 (US)
  • WILSON, James N.
    Philadelphia, PA 19103 (US)

(74) Representative: Manaton, Ross Timothy 
Bromhead Johnson
57-59 High Street Twyford, Berkshire RG10 9AJ
57-59 High Street Twyford, Berkshire RG10 9AJ (GB)

 
Remarks:
Claims filed after the date of filing of the application / after the date of receipt of the divisional application (Rule 68(4) EPC).
Remarks:
This application was filed on 04-06-2019 as a divisional application to the application mentioned under INID code 62.
 


(54) METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR


(57) A method of correcting singletons in a selected AAV sequence in order to increase the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid.