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EP 3 609 541 A1

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(43) Date of publication: 19.02.2020 Bulletin 2020/08 (21) Application number: 18780348.1 (22) Date of filing: 05.04.2018

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 16/18(2006.01) C07K 14/545(2006.01) (86) International application number: PCT/US2018/026340 (87) International publication number: WO 2018/187631 (11.10.2018 Gazette 2018/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.04.2017 US 201762482038 P 19.10.2017 US 201762574720 P (71) Applicant: Cornell University Ithaca, New York 14850 (US)	(72) Inventors: BABICH, John W. New York New York 10028 (US) KELLY, James M. New York New York 10021 (US) AMOR-COARASA, Alejandro New York New York 10021 (US) PONNALA, Shashikanth New York New York 10021 (US) (74) Representative: Nederlandsch Octrooibureau  P.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)