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(11)

EP 3 618 876 A1

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(43) Date of publication: 11.03.2020 Bulletin 2020/11 (21) Application number: 18729829.4 (22) Date of filing: 04.05.2018

(51) International Patent Classification (IPC):  A61K 45/06(2006.01) A61K 39/395(2006.01) C07K 16/22(2006.01) A61K 38/17(2006.01) C07K 14/71(2006.01) A61P 27/02(2006.01) (86) International application number: PCT/US2018/031255 (87) International publication number: WO 2018/208625 (15.11.2018 Gazette 2018/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 06.05.2017 US 201762502621 P (71) Applicant: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591 (US)	(72) Inventors: CAO, Jingtai Tarrytown, NY 10591 (US) CHEUNG, Eunice Tarrytown, NY 10591 (US) LOBOV, Ivan, B. New York, NY 10033 (US) (74) Representative: J A Kemp LLP  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)