(19)

(11)

EP 3 624 810 A1

(12)

(43) Date of publication: 25.03.2020 Bulletin 2020/13 (21) Application number: 18803111.6 (22) Date of filing: 17.05.2018

(51) International Patent Classification (IPC):  A61K 31/7115(2006.01) A61K 47/50(2017.01) A61K 31/7125(2006.01) (86) International application number: PCT/US2018/033265 (87) International publication number: WO 2018/213631 (22.11.2018 Gazette 2018/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 18.05.2017 US 201762507996 P 05.01.2018 US 201862614325 P (71) Applicant: The Regents of the University of California Oakland, CA 94607 (US)	(72) Inventors: NEL, E. Andre Sherman Oaks, California 91423 (US) MENG, Huan Los Angeles, California 90034 (US) LU, Jianqin Los Angeles, California 90034 (US) (74) Representative: Mewburn Ellis LLP  City Tower 40 Basinghall Street London EC2V 5DE London EC2V 5DE (GB)