(19)
(11) EP 3 630 134 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.01.2022 Bulletin 2022/03

(45) Mention of the grant of the patent:
08.12.2021 Bulletin 2021/49

(21) Application number: 18737743.7

(22) Date of filing: 31.05.2018
(51) International Patent Classification (IPC): 
A61K 35/28(2015.01)
A61K 9/00(2006.01)
 A61K 9/50(2006.01)
A61P 19/02(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 9/0024; A61P 19/02; A61K 35/28; A61K 9/5036; A61K 9/5068
(86) International application number:
PCT/US2018/035448
(87) International publication number:
WO 2018/222906 (06.12.2018 Gazette 2018/49)

(54)

FORMATION OF STABLE CARTILAGE

BILDUNG VON STABILEM KNORPEL

FORMATION DE CARTILAGE STABLE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 01.06.2017 US 201762513874 P

(43) Date of publication of application:
08.04.2020 Bulletin 2020/15

(73) Proprietors:
  • The United States of America as represented by The Secretary Department of Health and Human Services
    Bethesda, MD 20852-7660 (US)
  • Hadasit Medical Research Services and Development Ltd.
    9112001 Jerusalem (IL)
  • Shirvan, Mitchell
    4464518 Kfar Saba (IL)

(72) Inventors:
  • ROBEY, Pamela, Gehron
    Bethesda MD 20892 (US)
  • KUZNETSOV, Sergei
    Bethesda MD 20892 (US)
  • GORODETSKY, Raphael
    9112001 Jerusalem (IL)
  • HAILU-LAZMI, Astar
    9112001 Jerusalem (IL)
  • SHIRVAN, Mitchell
    4464518 Kfar Saba (IL)
  • FEATHERALL, Joseph
    Cleveland OH 44195 (US)

(74) Representative: Forresters IP LLP 
Skygarden Erika-Mann-Straße 11
80636 München
80636 München (DE)


(56) References cited: : 
WO-A1-2014/110353
US-A1- 2012 207 715
 US-A1- 2003 045 690
   
  • FERRIS DORA ET AL: "In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue", STEM CELLS INTERNATIONAL, 2012, XP055497102,
  • KUZNETSOV S A ET AL: "In vivo formation of bone and haematopoietic territories by transplanted human bone marrow stromal cells generated in medium with and without osteogenic supplements", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE JOHN WILEY & SONS LTD. UK, vol. 7, no. 3, March 2013 (2013-03), pages 226-235, XP055497104, ISSN: 1932-6254 cited in the application
  • FEATHERALL J ET AL: "In vivo formation of stable hyaline cartilage by transplantation of naive human bone marrow stromal cells", OSTEOARTHRITIS AND CARTILAGE 20180401 W.B. SAUNDERS LTD NLD, vol. 26, no. Supplement 1, 1 April 2018 (2018-04-01), XP055497107, ISSN: 1522-9653
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).