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EP 3 630 218 A1

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(43) Date of publication: 08.04.2020 Bulletin 2020/15 (21) Application number: 18809622.6 (22) Date of filing: 01.06.2018

(51) International Patent Classification (IPC):  A61M 1/10(2006.01) F04D 11/00(2006.01) A61F 2/24(2006.01) A61M 1/12(2006.01) F04D 29/40(2006.01) (86) International application number: PCT/US2018/035694 (87) International publication number: WO 2018/223060 (06.12.2018 Gazette 2018/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 01.06.2017 US 201762513927 P 09.06.2017 US 201715619335 (71) Applicants: Queen Mary University of London London Greater London E1 4NS (GB) Barts Health NHS Trust, The Royal London Hospital London, Greater London E1 1BB (GB) Korakianitis, Theodosios Ladue, MO 63124 (US) Rothman, Martin, T. Santa Rosa, CA 95409 (US)

(72) Inventors: KORAKIANITIS, Theodosios Santa Rosa, CA 95409 (US) ROTHMAN, Martin, T. Santa Rosa, CA 95409 (US) (74) Representative: Gill Jennings & Every LLP  The Broadgate Tower 20 Primrose Street London EC2A 2ES London EC2A 2ES (GB)