(19)

(11)

EP 3 630 944 A1

(12)

(43) Date of publication: 08.04.2020 Bulletin 2020/15 (21) Application number: 18810460.8 (22) Date of filing: 29.05.2018

(51) International Patent Classification (IPC):  C12N 1/20(2006.01) A61K 35/744(2015.01) C12R 1/25(2006.01) C12N 1/38(2006.01) C12R 1/125(2006.01) (86) International application number: PCT/IL2018/050588 (87) International publication number: WO 2018/220630 (06.12.2018 Gazette 2018/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.05.2017 WO PCT/IL2017/050603 19.11.2017 US 201762588365 P 18.03.2018 US 201862644528 P (71) Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) 7528809 Rishon-LeZion (IL)

(72) Inventor: SHEMESH, Moshe 7174635 ModiIn (IL) (74) Representative: AWA Sweden AB  P.O. Box 45086 104 30 Stockholm 104 30 Stockholm (SE)