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EP 3 634 450 A1

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(43) Date of publication: 15.04.2020 Bulletin 2020/16 (21) Application number: 18799088.2 (22) Date of filing: 10.05.2018

(51) International Patent Classification (IPC):  A61K 35/761(2015.01) C07K 14/075(2006.01) C12N 15/09(2006.01) C07K 14/005(2006.01) C12N 15/00(2006.01) C12N 15/86(2006.01) (86) International application number: PCT/US2018/032166 (87) International publication number: WO 2018/209154 (15.11.2018 Gazette 2018/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 10.05.2017 US 201762504318 P (71) Applicants: Massachusetts Eye and Ear Infirmary Boston, Massachusetts 02114 (US) The Schepens Eye Research Institute, Inc. Boston, MA 02114 (US)

(72) Inventors: VANDENBERGHE, Luk H. Weston Massachusetts 02493 (US) MAURER, Anna Claire Boston Massachusetts 02114 (US) (74) Representative: Sunderland, Charlotte  Forresters IP LLP Skygarden Erika-Mann-Strasse 11 80636 München 80636 München (DE)