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(11)

EP 3 634 457 A1

(12)

(43) Date of publication: 15.04.2020 Bulletin 2020/16 (21) Application number: 18723067.7 (22) Date of filing: 24.04.2018

(51) International Patent Classification (IPC):  A61K 36/899(2006.01) A61P 31/00(2006.01) A61K 36/534(2006.01) (86) International application number: PCT/IB2018/052843 (87) International publication number: WO 2018/224897 (13.12.2018 Gazette 2018/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.06.2017 ZA 201703890 (71) Applicant: University of Limpopo 0727 Sovenga (ZA)	(72) Inventors: DEMANA, Patrick, Hulisani 0727 Soventa (ZA) OLIVIER, Eugene, Ivan 0083 Pretoria (ZA) MULAMBA, Gedeon 0040 Pretoria (ZA) (74) Representative: Gibbs, Richard  Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS Glasgow G2 7JS (GB)