(19)
(11) EP 3 634 461 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.08.2023 Bulletin 2023/31

(45) Mention of the grant of the patent:
05.07.2023 Bulletin 2023/27

(21) Application number: 18729565.4

(22) Date of filing: 04.05.2018
(51) International Patent Classification (IPC): 
A61K 38/08(2019.01)
A61K 39/00(2006.01)
C07K 7/06(2006.01)
A61K 38/45(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 38/08; A61K 38/45; A61K 39/0011; C07K 7/06; C12Y 207/07049; A61P 35/00
 
C-Sets:
  1. A61K 38/08, A61K 2300/00;
  2. A61K 39/0011, A61K 2300/00;

(86) International application number:
PCT/EP2018/061609
(87) International publication number:
WO 2018/206462 (15.11.2018 Gazette 2018/46)

(54)

VACCINE TARGETING A CRYPTIC TERT EPITOPE, FOR TREATING LUNG CANCER IN A HLA-A*0201-POSITIVE NEVER-SMOKER OR LIGHT-FORMER SMOKER PATIENT

IMPFSTOFF ZUR ABZIELUNG AUF EIN KRYPTISCHES TERT-EPITOP ZUR BEHANDLUNG VON LUNGENKREBS IN EINEM HLA-A*0201-POSITIVEN PATIENTEN, DER NIE ODER WENIGER GERAUCHT HAT

VACCIN CIBLANT UN ÉPITOPE TERT CRYPTIQUE, POUR LE TRAITEMENT DU CANCER DU POUMON CHEZ UN NON FUMEUR POSITIF AU HLA-A*0201 OU CHEZ UN PATIENT ANCIEN FUMEUR LÉGER


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 09.05.2017 EP 17305527

(43) Date of publication of application:
15.04.2020 Bulletin 2020/16

(73) Proprietor: Kriptic Pharmaceuticals Limited
Dublin 1 (IE)

(72) Inventors:
  • KOSMATOPOULOS, Kostantinos (Kostas)
    75005 Paris (FR)
  • MENEZ-JAMET, Jeanne
    92120 Montrouge (FR)

(74) Representative: Santarelli 
Tour Trinity 1 bis Esplanade de la Défense
92035 Paris La Défense Cedex
92035 Paris La Défense Cedex (FR)


(56) References cited: : 
WO-A2-2006/120038
   
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  • LAN QING ET AL: "Longer Telomere Length in Peripheral White Blood Cells Is Associated with Risk of Lung Cancer and the rs2736100 (CLPTM1L-TERT) Polymorphism in a Prospective Cohort Study among Women in China", PLOS ONE, vol. 8, no. 3, March 2013 (2013-03), XP055415765, ISSN: 1932-6203
  • N. A. RIZVI ET AL: "Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer", SCIENCE, vol. 348, no. 6230, 3 April 2015 (2015-04-03), pages 124-128, XP055322846, ISSN: 0036-8075, DOI: 10.1126/science.aaa1348
  • ZHANG TENGFEI ET AL: "The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis", ONCOTARGET, vol. 7, no. 45, 8 November 2016 (2016-11-08), pages 73068-73079, XP055415778,
  • DOGAN SNJEZANA ET AL: "Molecular Epidemiology of EGFR and KRAS Mutations in 3,026 Lung Adenocarcinomas: Higher Susceptibility of Women to Smoking-Related KRAS-Mutant Cancers", CLINICAL CANCER RESEARCH, vol. 18, no. 22, November 2012 (2012-11), pages 6169-6177, XP055415781,
  • BUCCHERI G ET AL: "Karnofsky and ECOG performance status scoring in lung cancer: A prospective, longitudinal study of 536 patients from a single institution", EUROPEAN JOURNAL OF CANCER, ELSEVIER, AMSTERDAM, NL, vol. 32, no. 7, 1 June 1996 (1996-06-01), pages 1135-1141, XP027246652, ISSN: 0959-8049 [retrieved on 1996-06-01]
  • TOMOHIRO TAMURA ET AL: "Specific organ metastases and survival in metastatic non-small-cell lung cancer", MOLECULAR AND CLINICAL ONCOLOGY, vol. 3, no. 1, 4 September 2014 (2014-09-04), pages 217-221, XP055497469, GR ISSN: 2049-9450, DOI: 10.3892/mco.2014.410
   
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