(19)

(11)

EP 3 634 483 A1

(12)

(43) Date of publication: 15.04.2020 Bulletin 2020/16 (21) Application number: 18739638.7 (22) Date of filing: 08.06.2018

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61P 35/00(2006.01) C07K 16/28(2006.01) A61K 39/00(2006.01) (86) International application number: PCT/IB2018/054167 (87) International publication number: WO 2018/225033 (13.12.2018 Gazette 2018/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.06.2017 US 201762517309 P 03.05.2018 US 201862666278 P (71) Applicant: GlaxoSmithKline Intellectual Property Development Limited Brentford, Middlesex TW8 9GS (GB)

(72) Inventors: BI, Meixia Collegeville Pennsylvania 19426 (US) HOPSON, Christopher B. Collegeville Pennsylvania 19426 (US) MAYES, Patrick A. Devon Pennsylvania 19333 (US) YADAVILLI, Sapna Collegeville Pennsylvania 19426-0989 (US) (74) Representative: Kim, Young In Timothy  GlaxoSmithKline Global Patents GSK House (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)