| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
31.05.2017 US 201762513251 P
|
| (43) |
Date of publication of application: |
|
15.04.2020 Bulletin 2020/16 |
| (73) |
Proprietor: Napo Pharmaceuticals, Inc. |
|
San Francisco, CA 94104 (US) |
|
| (72) |
Inventors: |
|
- CONTE, Lisa, A.
San Francisco
CA 94105 (US)
- CHATURVEDI, Pravin, R.
Andover
MA 01810 (US)
|
| (74) |
Representative: Thomann, William John |
|
ZSP
Patentanwälte PartG mbB
Hansastraße 32 80686 München 80686 München (DE) |
| (56) |
References cited: :
WO-A1-98/16111 US-A1- 2012 202 876
|
US-A1- 2007 254 050
|
|
| |
|
|
- "Current Concepts in Colonic Disorders", 5 January 2012, INTECH, ISBN: 978-953-30-7957-8,
article CLAUDIA VELAZQUEZ ET AL: "Management of Secretory Diarrhea", pages: 67 - 84,
XP055561545, DOI: 10.5772/28528
- VOGEL GEORG F. ET AL: "Towards understanding microvillus inclusion disease", MOLECULAR
AND CELLULAR PEDIATRICS, vol. 3, no. 1, 1 December 2016 (2016-12-01), XP093023273,
Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733813/pdf/40348_2016_Article_31.pdf>
DOI: 10.1186/s40348-016-0031-0
- OLLER HALEY ET AL: "DEVELOPMENT OF PATIENT-DERIVED ENTEROIDS AS A THERAPEUTIC PLATFORM
FOR MICROVILLUS INCLUSION DISEASE", 31 May 2022 (2022-05-31), pages S10, XP093079965,
Retrieved from the Internet <URL:https://www.sciencedirect.com/science/article/pii/S0016508522600258/pdfft?md5=8d86d9550657e3d6bedb7a5fcbda2bc2&pid=1-s2.0-S0016508522600258-main.pdf>
[retrieved on 20230907]
- DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US;
March 2016 (2016-03-01), LOCK OLGA ET AL: "Bioactive Compounds from Plants Used in
Peruvian Traditional Medicine.", Database accession no. NLM27169179
- TRADTRANTIP LUKMANEE ET AL: "Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin
Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride
Channels", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL
THERAPEUTICS, US, vol. 77, no. 1, 1 January 2010 (2010-01-01), pages 69 - 78, XP009170161,
ISSN: 0026-895X, DOI: 10.1124/MOL.109.061051
- JAY R. THIAGARAJAH ET AL: "Secretory diarrhoea: mechanisms and emerging therapies",
NATURE REVIEWS GASTROENTEROLOGY, vol. 12, no. 8, 30 June 2015 (2015-06-30), London,
pages 446 - 457, XP55764695, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2015.111
- JONES KENNETH: "Review of sangre de drago (Croton lechleri)-- a South American tree
sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and
wounds: traditional uses to clinical research", JOURNAL OF ALTERNATIVE AND COMPLEMENTARY
MEDICINE, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 9, no. 6, 1 December 2003 (2003-12-01),
pages 877 - 896, XP009141651, ISSN: 1075-5535
- RAO MRINALINI C.: "Oral Rehydration Therapy: New Explanations for an Old Remedy",
ANNUAL REVIEW OF PHYSIOLOGY., vol. 66, no. 1, 1 March 2004 (2004-03-01), US, pages
385 - 417, XP055835704, ISSN: 0066-4278, Retrieved from the Internet <URL:https://www.annualreviews.org/doi/pdf/10.1146/annurev.physiol.66.032902.134726>
DOI: 10.1146/annurev.physiol.66.032902.134726
- JAY R. THIAGARAJAH ET AL: "Discovery and Development of Antisecretory Drugs for Treating
Diarrheal Diseases", CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, vol. 12, no. 2, 1 February
2014 (2014-02-01), AMSTERDAM, NL, pages 204 - 209, XP055764693, ISSN: 1542-3565, DOI:
10.1016/j.cgh.2013.12.001
- JAY R. THIAGARAJAH ET AL: "Secretory diarrhoea: mechanisms and emerging therapies",
NATURE REVIEWS / GASTROENTEROLOGY & HEPATOLOGY, vol. 12, no. 8, 30 June 2015 (2015-06-30),
US, pages 446 - 457, XP055764695, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2015.111
- VELAZQUEZ ET AL.: "Management of Secretory Diarrhea", CURRENT CONCEPTS IN COLONIC
DISORDERS , INTECH, January 2012 (2012-01-01), pages 67 - 84, XP055561545
|
|