ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*J0009290-CORR01The file contains technical information submitted after the application was filed and not included in this specification3634581CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120240911W173deBibliographieenBibliographyfrBibliographieEP18810153.9201805312019121020220224enenen201762513251 P20170531US2024091120243720200415202016202407312024312024042220240911202437A61K 36/47 20060101AFI20240403BHEP A61K 31/535 20060101ALI20240403BHEP A61K 9/00 20060101ALI20240403BHEP A61K 9/20 20060101ALI20240403BHEP A61K 9/48 20060101ALI20240403BHEP A61P 1/00 20060101ALI20240403BHEP A61P 1/04 20060101ALI20240403BHEP A61P 1/12 20060101ALI20240403BHEP A61K 9/28 20060101ALI20240403BHEP A61P 1/00 20180101 FI20190109BHEP A61P 1/12 20180101 LI20190109BHEP A61P 1/04 20180101 LI20190109BHEP A61K 31/535 20130101 LI20190612BHEP A61K 9/0095 20130101 LA20190613BHEP A61K 9/20 20130101 LA20190613BHEP A61K 9/28 20130101 LA20190613BHEP A61K 9/48 20130101 LA20190613BHEP deZUSAMMENSETZUNG ZUR VERWENDUNG ZUR BEHANDLUNG VON KONGENITALER DIARRHÖenCOMPOSITIONS FOR USE IN TREATING CONGENITAL DIARRHEA DISORDERfrCOMPOSITIONS POUR UTILISATION DANS LE TRAITEMENT D' UN TROUBLE DE LA DIARRHÉE CONGÉNITALEWO-A1-98/16111US-A1- 2007 254 050US-A1- 2012 202 876"Current Concepts in Colonic Disorders", 5 January 2012, INTECH, ISBN: 978-953-30-7957-8, article CLAUDIA VELAZQUEZ ET AL: "Management of Secretory Diarrhea", pages: 67 - 84, XP055561545, DOI: 10.5772/28528VOGEL GEORG F. ET AL: "Towards understanding microvillus inclusion disease", MOLECULAR AND CELLULAR PEDIATRICS, vol. 3, no. 1, 1 December 2016 (2016-12-01), XP093023273, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733813/pdf/40348_2016_Article_31.pdf> DOI: 10.1186/s40348-016-0031-0OLLER HALEY ET AL: "DEVELOPMENT OF PATIENT-DERIVED ENTEROIDS AS A THERAPEUTIC PLATFORM FOR MICROVILLUS INCLUSION DISEASE", 31 May 2022 (2022-05-31), pages S10, XP093079965, Retrieved from the Internet <URL:https://www.sciencedirect.com/science/article/pii/S0016508522600258/pdfft?md5=8d86d9550657e3d6bedb7a5fcbda2bc2&pid=1-s2.0-S0016508522600258-main.pdf> [retrieved on 20230907]DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; March 2016 (2016-03-01), LOCK OLGA ET AL: "Bioactive Compounds from Plants Used in Peruvian Traditional Medicine.", Database accession no. NLM27169179TRADTRANTIP LUKMANEE ET AL: "Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 77, no. 1, 1 January 2010 (2010-01-01), pages 69 - 78, XP009170161, ISSN: 0026-895X, DOI: 10.1124/MOL.109.061051JAY R. THIAGARAJAH ET AL: "Secretory diarrhoea: mechanisms and emerging therapies", NATURE REVIEWS GASTROENTEROLOGY, vol. 12, no. 8, 30 June 2015 (2015-06-30), London, pages 446 - 457, XP55764695, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2015.111JONES KENNETH: "Review of sangre de drago (Croton lechleri)-- a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research", JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 9, no. 6, 1 December 2003 (2003-12-01), pages 877 - 896, XP009141651, ISSN: 1075-5535RAO MRINALINI C.: "Oral Rehydration Therapy: New Explanations for an Old Remedy", ANNUAL REVIEW OF PHYSIOLOGY., vol. 66, no. 1, 1 March 2004 (2004-03-01), US, pages 385 - 417, XP055835704, ISSN: 0066-4278, Retrieved from the Internet <URL:https://www.annualreviews.org/doi/pdf/10.1146/annurev.physiol.66.032902.134726> DOI: 10.1146/annurev.physiol.66.032902.134726JAY R. THIAGARAJAH ET AL: "Discovery and Development of Antisecretory Drugs for Treating Diarrheal Diseases", CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, vol. 12, no. 2, 1 February 2014 (2014-02-01), AMSTERDAM, NL, pages 204 - 209, XP055764693, ISSN: 1542-3565, DOI: 10.1016/j.cgh.2013.12.001JAY R. THIAGARAJAH ET AL: "Secretory diarrhoea: mechanisms and emerging therapies", NATURE REVIEWS / GASTROENTEROLOGY & HEPATOLOGY, vol. 12, no. 8, 30 June 2015 (2015-06-30), US, pages 446 - 457, XP055764695, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2015.111VELAZQUEZ ET AL.: "Management of Secretory Diarrhea", CURRENT CONCEPTS IN COLONIC DISORDERS , INTECH, January 2012 (2012-01-01), pages 67 - 84, XP05556154520210122CONTE, Lisa, A.301 Main St. Apt. 30GSan Francisco CA 94105USCHATURVEDI, Pravin, R.27 Jenkins Rd.Andover MA 01810USNapo Pharmaceuticals, Inc.1019791951001-2 PCTEP200 Pine Street, Suite 400San Francisco, CA 94104USThomann, William John101685981ZSP Patentanwälte PartG mbB Hansastraße 3280686 MünchenDEALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRUS201803546820180531enWO201822291920181206201849