(19)

(11)

EP 3 634 634 A1

(12)

(43) Date of publication: 15.04.2020 Bulletin 2020/16 (21) Application number: 18813844.0 (22) Date of filing: 06.06.2018

(51) International Patent Classification (IPC):  B01L 3/00(2006.01) G01N 33/50(2006.01) G01N 33/543(2006.01) G01N 33/48(2006.01) G01N 33/53(2006.01) G01N 33/549(2006.01) (86) International application number: PCT/US2018/036348 (87) International publication number: WO 2018/226891 (13.12.2018 Gazette 2018/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 06.06.2017 US 201762515876 P (71) Applicant: Northwestern University Evanston, IL 60208 (US)

(72) Inventors: KELSO, David M. Evanston Illinois 60208 (US) AGARWAL, Abhishek K. Evanston Illinois 60208 (US) MCFALL,Sally M. Evanston Illinois 60208 (US) WESTBERG, Tom Evanston Illinois 60208 (US) BUTZLER, Matthew Austin Evanston Illinois 60208 (US) REED, Jennifer L. Evanston Illinois 60208 (US) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)