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EP 3 634 952 A1

(12)

(43) Date of publication: 15.04.2020 Bulletin 2020/16 (21) Application number: 18733953.6 (22) Date of filing: 07.06.2018

(51) International Patent Classification (IPC):  C07D 233/36(2006.01) C07D 305/08(2006.01) A61K 31/4166(2006.01) A61K 31/44(2006.01) A61P 35/00(2006.01) A61P 9/00(2006.01) A61P 27/00(2006.01) C07D 311/58(2006.01) C07C 233/41(2006.01) C07D 213/65(2006.01) A61K 31/337(2006.01) A61K 31/165(2006.01) A61P 25/00(2006.01) A61P 3/00(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/IN2018/050375 (87) International publication number: WO 2018/225093 (13.12.2018 Gazette 2018/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.06.2017 WO PCT/IB2017/053373 06.12.2017 US 201762595245 P 18.01.2018 IN 201811002087 (71) Applicant: GlaxoSmithKline Intellectual Property Development Limited Brentford, Middlesex TW8 9GS (GB)

(72) Inventors: AXTEN, Jeffrey Michael Collegeville, Pennsylvania 19426 (US) DEMARTINO, Michael P. Collegeville, Pennsylvania 19426 (US) EVANS, Karen Anderson Collegeville, Pennsylvania 19426 (US) RALPH, Jeffrey M Collegeville, Pennsylvania 19426 (US) KALITA, Biswajit Yeshwanthpur Bangalore (IN) (74) Representative: Price, Susanna Clare Hopley  GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)