(19)

(11)

EP 3 638 240 A2

(12)

(88) Date of publication A3: 14.02.2019 (43) Date of publication: 22.04.2020 Bulletin 2020/17 (21) Application number: 18762131.3 (22) Date of filing: 15.06.2018

(51) International Patent Classification (IPC):  A61K 31/485(2006.01) A61P 25/36(2006.01) A61K 47/34(2017.01) (86) International application number: PCT/IB2018/000770 (87) International publication number: WO 2018/229551 (20.12.2018 Gazette 2018/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.06.2017 US 201762521121 P 13.10.2017 US 201762572331 P 16.10.2017 US 201762572996 P 13.12.2017 US 201762598338 P 20.02.2018 US 201862632995 P 11.04.2018 US 201862656216 P 05.06.2018 US 201862680935 P (71) Applicant: Indivior UK Limited Priory Park Hull HU4 7DY (GB)

(72) Inventors: LAFFONT, Celine, M. Richmond, VA 23235 (US) YOUNG, Malcolm, A. Richmond, VA 23235 (US) FOX, Norma, L. Richmond, VA 23235 (US) HAIGHT, Barbara, R. Richmond, VA 23235 (US) LEARNED, Susan, M. Richmond, VA 23235 (US) (74) Representative: HGF Limited  1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)