(19)
(11) EP 3 638 814 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.06.2023 Bulletin 2023/25

(45) Mention of the grant of the patent:
10.05.2023 Bulletin 2023/19

(21) Application number: 18733500.5

(22) Date of filing: 05.06.2018
(51) International Patent Classification (IPC): 
C12Q 1/6886(2018.01)
(52) Cooperative Patent Classification (CPC):
C12Q 1/6886; C12Q 2600/112; C12Q 2600/158
(86) International application number:
PCT/US2018/036084
(87) International publication number:
WO 2018/231589 (20.12.2018 Gazette 2018/51)

(54)

METHOD FOR DETERMINING LYMPHOMA TYPE

VERFAHREN ZUR BESTIMMUNG DES LYMPHOMTYPS

PROCÉDÉ DE DÉTERMINATION DE TYPE DE LYMPHOME


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 14.06.2017 US 201762519728 P

(43) Date of publication of application:
22.04.2020 Bulletin 2020/17

(73) Proprietors:
  • The United States of America, as Represented by The Secretary, Department of Health and Human Services
    Bethesda, Maryland 20892-7788 (US)
  • British Columbia Cancer Agency Branch
    Vancouver, BC V5Z 4E6 (CA)
  • Mayo Foundation for Medical Education and Research
    Rochester, Minnesota 55905 (US)
  • Julius-Maximilians-Universitaet Wuerzburg
    97070 Wuerzburg (DE)
  • The Board of Regents of the University of Nebraska
    Lincoln, NE 68583-0745 (US)
  • Oslo University Hospital HF
    0450 Oslo (NO)
  • Hospital Clinic De Barcelona
    08036 Barcelona (ES)
  • Universitat de Barcelona
    08028 Barcelona (ES)
  • Institut D'Investigacions Biomèdiques August Pi I Sunyer - IDIBAPS
    08036 Barcelona (ES)
  • Robert Bosch Gesellschaft für medizinische Forschung mbH
    70376 Stuttgart (DE)
  • Oregon Health & Science University
    Portland, OR 97239 (US)
  • City of Hope
    Duarte, CA 91010-3000 (US)
  • The Cleveland Clinic Foundation
    Cleveland, OH 44195 (US)

(72) Inventors:
  • STAUDT, Louis M.
    Bethesda, Maryland 20814 (US)
  • STEIDL, Christian
    North Vancouver, British Columbia V7J 2H5 (CA)
  • MOTTOK, Anja
    89077 Ulm (DE)
  • WRIGHT, George W.
    Rockville, Maryland 20853 (US)
  • SCOTT, David William
    Vancouver, British Columbia V6S 0K3 (CA)
  • RIMSZA, Lisa M.
    Scottsdale, Arizona 85266 (US)
  • ROSENWALD, Andreas
    97078 Würzburg (DE)
  • GASCOYNE, Randy
    North Vancouver British Columbia V7M 1S3 (CA)
  • GREINER, Timothy
    Council Bluffs, Iowa 51503 (US)
  • WEISENBURGER, Dennis
    Glendora, California 91741 (US)
  • SMELAND, Erlend B.
    0778 Oslo (NO)
  • DELABIE, Jan
    Toronto, Ontario M6P 2V9 (CA)
  • CAMPO GUERRI, Elias
    08036 Barcelona (ES)
  • OTT, German
    74321 Bietigheim-Bissingen (DE)
  • BRAZIEL, Rita
    West Linn, Oregon 97068 (US)
  • JAFFE, Elaine S.
    Great Falls, Virginia 22066 (US)
  • FU, Kai
    Omaha, Nebraska 68130 (US)
  • CHAN, Wing C.
    Pasadena, California, 91107 (US)
  • SONG, Joo
    Duarte, California 91010 (US)
  • COOK, James R.
    Shaker Heights, Ohio 44120 (US)

(74) Representative: Maiwald GmbH 
Elisenhof Elisenstraße 3
80335 München
80335 München (DE)


(56) References cited: : 
WO-A1-2015/069790
WO-A2-2005/024043
   
  • A. MOTTOK ET AL: "MOLECULAR CLASSIFICATION OF PRIMARY MEDIASTINAL LARGE B CELL LYMPHOMA USING FORMALIN-FIXED, PARAFFIN-EMBEDDED TISSUE SPECIMENS - AN LLMPP PROJECT", HEMATOLOGICAL ONCOLOGY, vol. 35, 7 June 2017 (2017-06-07), pages 59-60, XP055495961, US ISSN: 0278-0232, DOI: 10.1002/hon.2437_46
  • D. W. SCOTT ET AL: "Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue", BLOOD, vol. 123, no. 8, 20 February 2014 (2014-02-20), pages 1214-1217, XP055495536, US ISSN: 0006-4971, DOI: 10.1182/blood-2013-11-536433
  • ROSENWALD A ET AL: "Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 198, no. 6, 15 September 2003 (2003-09-15), pages 851-862, XP002396795, ISSN: 0022-1007, DOI: 10.1084/JEM.20031074
  • LENZ G ET AL: "Stromal gene signatures in large-B-cell lymphomas", NEW ENGLAND JOURNAL OF MEDICINE, THE - NEJM, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 359, no. 22, 27 November 2008 (2008-11-27), pages 2313-2323, XP002551776, ISSN: 1533-4406, DOI: 10.1056/NEJMOA0802885
  • M. H. VELDMAN-JONES ET AL: "Reproducible, Quantitative, and Flexible Molecular Subtyping of Clinical DLBCL Samples Using the NanoString nCounter System", CLINICAL CANCER RESEARCH, vol. 21, no. 10, 9 October 2014 (2014-10-09), pages 2367-2378, XP055495781, US ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-14-0357 & Veldman-Jones ET AL: "Supplemental Table 1", Clinical Cancer Research 21(10): 2367-2378 (2014), 9 January 2014 (2014-01-09), XP055495789, Retrieved from the Internet: URL:http://clincancerres.aacrjournals.org/ highwire/filestream/131853/field_highwire_ adjunct_files/5/126978_2_supp_2633385_nfzh bv.pptx [retrieved on 2018-07-27]
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).