(19)
(11) EP 3 641 794 A1

(12)

(43) Date of publication:
29.04.2020 Bulletin 2020/18

(21) Application number: 18820337.6

(22) Date of filing: 25.06.2018
(51) International Patent Classification (IPC): 
A61K 35/30(2015.01)
C12N 5/079(2010.01)
(86) International application number:
PCT/US2018/039292
(87) International publication number:
WO 2018/237383 (27.12.2018 Gazette 2018/52)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 23.06.2017 US 201762524282 P
31.01.2018 US 201862624258 P

(71) Applicant: The Trustees of Columbia University in the City of New York
New York, NY 10027 (US)

(72) Inventor:
  • LEFORT, Roger
    New York NY 10027 (US)

(74) Representative: Elkington and Fife LLP 
Prospect House 8 Pembroke Road
Sevenoaks, Kent TN13 1XR
Sevenoaks, Kent TN13 1XR (GB)

   


(54) METHODS OF PREVENTING AND TREATING DISEASES CHARACTERIZED BY SYNAPTIC DYSFUNCTION AND NEURODEGENERATION INCLUDING ALZHEIMER'S DISEASE