(19)

(11)

EP 3 641 891 A1

(12)

(43) Date of publication: 29.04.2020 Bulletin 2020/18 (21) Application number: 18820741.9 (22) Date of filing: 21.06.2018

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07K 14/47(2006.01) C07K 1/00(2006.01) (86) International application number: PCT/US2018/038813 (87) International publication number: WO 2018/237178 (27.12.2018 Gazette 2018/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.06.2017 US 201762523509 P 12.10.2017 US 201762571537 P (71) Applicant: William Marsh Rice University Houston, TX 77005 (US)	(72) Inventors: NICOLAOU, Kyriacos C. Houston TX 77251-1892 (US) BELLAVANCE, Gabriel Houston TX 77251-1892 (US) BUCHMAN, Marek Houston TX 77251-1892 (US) PULUKURI, Kiran Kumar Houston TX 77251-1892 (US) RIGOL, Stephan Houston TX 77251-1892 (US) (74) Representative: Potter Clarkson  The Belgrave Centre Talbot Street Nottingham NG1 5GG Nottingham NG1 5GG (GB)