(19)
(11) EP 3 642 330 A1

(12)

(43) Date of publication:
29.04.2020 Bulletin 2020/18

(21) Application number: 18742616.8

(22) Date of filing: 22.06.2018
(51) International Patent Classification (IPC): 
C12N 5/077(2010.01)
A61K 35/545(2015.01)
 A61K 35/14(2015.01)
C12Q 1/68(2018.01)
(86) International application number:
PCT/SG2018/050304
(87) International publication number:
WO 2018/236289 (27.12.2018 Gazette 2018/52)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 22.06.2017 US 201762523700 P

(71) Applicant: National University of Singapore
Singapore 119077 (SG)

(72) Inventors:
  • TRYGGVASON, Karl
    Singapore 169857 (SG)
  • YAP, Yan Wen
    Singapore 169857 (SG)
  • MORENO MORAL, Aida
    Singapore 169857 (SG)

(74) Representative: Kador & Partner PartG mbB 
Corneliusstraße 15
80469 München
80469 München (DE)

   


(54) DIFFERENTIATION OF PLURIPOTENT STEM CELLS AND CARDIAC PROGENITOR CELLS INTO STRIATED CARDIOMYOCYTE FIBERS USING LAMININS LN-511, LN-521 AND LN-221