(19)
(11) EP 3 644 999 A1

(12)

(43) Date of publication:
06.05.2020 Bulletin 2020/19

(21) Application number: 18823719.2

(22) Date of filing: 29.06.2018
(51) International Patent Classification (IPC): 
A61K 31/454(2006.01)
A61K 47/12(2006.01)
 A61K 39/395(2006.01)
(86) International application number:
PCT/US2018/040286
(87) International publication number:
WO 2019/006299 (03.01.2019 Gazette 2019/01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 30.06.2017 US 201762527744 P
05.04.2018 US 201862653436 P
17.05.2018 US 201862673064 P

(71) Applicant: Celgene Corporation
Summit, NJ 07901 (US)

(72) Inventors:
  • BUCHHOLZ, Tonia, J.
    Moss Beach CA 94038 (US)
  • CARMICHAEL, James
    Edwalton NG12 4AL (GB)
  • CARRANCIO, Soraya
    San Diego CA 92122 (US)
  • FAN, Jinhong
    San Mateo CA 94403 (US)
  • GUPTA, Rajan
    Bridgewater NJ 08807 (US)
  • LU, Gang
    San Diego CA 92130 (US)
  • MACBETH, Kyle
    San Francisco CA 94103 (US)
  • PACE, Emily
    Orinda CA 94563 (US)
  • PIERCE, Daniel
    Belmont CA 94002 (US)
  • POURDEHNAD, Michael
    San Francisco CA 94114 (US)
  • PU, Yu
    East Hanover NJ 07936 (US)
  • WANG, Peng
    Westfield NJ 07090 (US)
  • WU, Naijun
    Princeton NJ 08540 (US)
  • YAO, Sheena
    San Francisco CA 94122 (US)

(74) Representative: Jones Day 
Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11
80538 München
80538 München (DE)

   


(54) COMPOSITIONS AND METHODS OF USE OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL) METHYL) -2,2-DIFLUOROACETAMIDE