(19)

(11)

EP 3 645 012 A1

(12)

(43) Date of publication: 06.05.2020 Bulletin 2020/19 (21) Application number: 18823174.0 (22) Date of filing: 28.06.2018

(51) International Patent Classification (IPC):  A61K 31/711(2006.01) C12P 19/34(2006.01) C12N 15/85(2006.01) (86) International application number: PCT/US2018/039980 (87) International publication number: WO 2019/006107 (03.01.2019 Gazette 2019/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.06.2017 US 201762525787 P (71) Applicant: University Of South Florida Tampa, FL 33612 (US)	(72) Inventors: NASH, Kevin Ron Temple Terrace Florida 33617 (US) WEEBER, Edwin John Apollo Beach Florida 33572 (US) (74) Representative: Cabinet Chaillot  16/20, avenue de l'Agent Sarre B.P. 74 92703 Colombes Cedex 92703 Colombes Cedex (FR)