| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
07.07.2017 GB 201710984
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| (43) |
Date of publication of application: |
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13.05.2020 Bulletin 2020/20 |
| (60) |
Divisional application: |
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24178098.0 / 4410986 |
| (73) |
Proprietor: Kymab Limited |
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Cambridge CB22 3AT (GB) |
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| (72) |
Inventors: |
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- LEE, E-Chiang
Cambridge, Cambridgeshire CB22 3AT (GB)
- WANG, Wei
Cambridge, Cambridgeshire CB22 3AT (GB)
- BLACKWOOD, John Kenneth
Cambridge CB22 3AT (GB)
- MAGLIOZZI, Roberto
Cambridge CB22 3AT (GB)
- WOOD, Andrew
Cambridge, CB22 3AT (GB)
|
| (74) |
Representative: CMS Cameron McKenna Nabarro
Olswang LLP |
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Cannon Place
78 Cannon Street
London EC4N 6AF
London EC4N 6AF (GB) |
| (56) |
References cited: :
EP-A1- 2 147 594
WO-A2-2006/117699
US-A1- 2011 195 454
US-A1- 2013 263 292
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WO-A1-2014/130690
US-A1- 2006 015 957
US-A1- 2012 021 409
US-A1- 2018 298 112
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- ODEGARD VALERIE H ET AL: "Targeting of somatic hypermutation", NATURE REVIEWS IMMUNOLOGY,
NATURE PUBLISHING GROUP UK, LONDON, vol. 6, no. 8, 1 August 2006 (2006-08-01), pages
573 - 583, ISSN: 1474-1733, DOI: 10.1038/NRI1896
- BETZ A G ET AL: "Elements regulating somatic hypermutation of an immunoglobulin @k
gene: Critical role for the intron enhancer/matrix attachment region", CELL, ELSEVIER,
AMSTERDAM NL, vol. 77, no. 2, 22 April 1994 (1994-04-22), pages 239 - 248, ISSN: 0092-8674,
[retrieved on 19940422], DOI: 10.1016/0092-8674(94)90316-6
- BETZ A G ET AL: "Elements regulating somatic hypermutation of an immunoglobulin @k
gene: Critical role for the intron enhancer/matrix attachment region", CELL, ELSEVIER,
AMSTERDAM NL, vol. 77, no. 2, 22 April 1994 (1994-04-22), pages 239 - 248, XP024245265,
ISSN: 0092-8674, [retrieved on 19940422], DOI: 10.1016/0092-8674(94)90316-6
- ODEGARD VALERIE H ET AL: "Targeting of somatic hypermutation", NATURE REVIEWS IMMUNOLOGY,
NATURE PUBLISHING GROUP UK, LONDON, vol. 6, no. 8, 1 August 2006 (2006-08-01), pages
573 - 583, XP002556635, ISSN: 1474-1733, DOI: 10.1038/NRI1896
- MATTHEW A. INLAY ET AL: "Critical roles of the immunoglobulin intronic enhancers in
maintaining the sequential rearrangement of IgH and Igk loci", THE JOURNAL OF EXPERIMENTAL
MEDICINE, vol. 203, no. 7, 10 July 2006 (2006-07-10), US, pages 1721 - 1732, XP055516424,
ISSN: 0022-1007, DOI: 10.1084/jem.20052310
- DIAZ M ET AL: "Somatic immunoglobulin hypermutation", CURRENT OPINION IN IMMUNOL,
ELSEVIER, OXFORD, GB, vol. 14, no. 2, 1 April 2002 (2002-04-01), pages 235 - 240,
XP004340052, ISSN: 0952-7915, DOI: 10.1016/S0952-7915(02)00327-8
- T. PERLOT ET AL: "Elucidation of IgH intronic enhancer functions via germ-line deletion",
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol.
102, no. 40, 4 October 2005 (2005-10-04), pages 14362 - 14367, XP055516419, ISSN:
0027-8424, DOI: 10.1073/pnas.0507090102
- WINTER D B ET AL: "Insertion of 2 kb of bacteriophage DNA between an immunoglobulin
promoter and leader exon stops somatic hypermutation in a kappa transgene", MOLECULAR
IMMUNOLOGY, PERGAMON, GB, vol. 34, no. 5, 1 April 1997 (1997-04-01), pages 359 - 366,
XP002556634, ISSN: 0161-5890, [retrieved on 19971010], DOI: 10.1016/S0161-5890(97)00073-4
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