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(11)

EP 3 648 757 A1

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(43) Date of publication: 13.05.2020 Bulletin 2020/20 (21) Application number: 17916806.7 (22) Date of filing: 03.07.2017

(51) International Patent Classification (IPC):  A61K 31/337(2006.01) A61K 33/24(2019.01) A61K 31/704(2006.01) (86) International application number: PCT/US2017/040584 (87) International publication number: WO 2019/009879 (10.01.2019 Gazette 2019/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (71) Applicant: Development Center for Biotechnology New Taipei City 22180 (TW)

(72) Inventors: LAI, Jiann-Shiun New Taipei City 22180 (TW) AI, Li-Shuang New Taipei City 22180 (TW) LAI, Yan-da New Taipei City 22180 (TW) WU, Yen-Yu New Taipei City 22180 (TW) TSAI, Yi-San New Taipei City 22180 (TW) TSAI, Yi-Jiue New Taipei City 22180 (TW) HUANG, Juo-Yu New Taipei City 22180 (TW) YU, Cheng-Chou New Taipei City 22180 (TW) HSU, Chuan-Lung New Taipei City 22180 (TW) KUAN, Chien-Tsun New Taipei City 22180 (TW) LAI, Szu-Liang New Taipei City 22180 (TW) WANG, Li-Ya New Taipei City 22180 (TW) (74) Representative: 2K Patentanwälte Blasberg Kewitz & Reichel  Partnerschaft mbB Schumannstrasse 27 60325 Frankfurt am Main 60325 Frankfurt am Main (DE)