(19)
(11) EP 3 650 534 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.04.2023 Bulletin 2023/17

(45) Mention of the grant of the patent:
15.03.2023 Bulletin 2023/11

(21) Application number: 18828501.9

(22) Date of filing: 05.02.2018
(51) International Patent Classification (IPC): 
C12N 1/21(2006.01)
C07K 14/245(2006.01)
C12N 9/12(2006.01)
C12N 9/16(2006.01)
 C12P 19/30(2006.01)
C12N 9/04(2006.01)
C12N 9/14(2006.01)
C12N 15/52(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 9/16; C12N 9/14; C12N 9/0006; C12N 9/1205; C12N 9/1241; C07K 14/245; C12N 15/52; C12P 19/305; C12Y 301/03005; C12Y 306/01026; C12Y 101/99001; C12Y 301/03001; C12Y 301/03002; C12Y 207/01032; C12Y 207/07015
(86) International application number:
PCT/CN2018/075238
(87) International publication number:
WO 2019/007055 (10.01.2019 Gazette 2019/02)

(54)

RECOMBINANT MICROORGANISM FOR PRODUCING CYTIDINE DIPHOSPHATE AND METHOD FOR PRODUCING CYTIDINE DIPHOSPHATE

REKOMBINANTER MIKROORGANISMUS ZUR HERSTELLUNG VON CYTIDINDIPHOSPHAT UND VERFAHREN ZUR HERSTELLUNG VON CYTIDINDIPHOSPHAT

MICRO-ORGANISME RECOMBINANT POUR LA PRODUCTION DE CYTIDINE DIPHOSPHATE ET PROCÉDÉ DE PRODUCTION DE CYTIDINE DIPHOSPHATE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 07.07.2017 CN 201710549120

(43) Date of publication of application:
13.05.2020 Bulletin 2020/20

(73) Proprietor: Jiangsu Cheng Yi Pharmaceutical Co., Ltd.
CHINA 223002 (CN)

(72) Inventors:
  • JIANG, Junjun
    Suzhou Jiangsu 215600 (CN)
  • FAN, Junyin
    Suzhou Jiangsu 215600 (CN)
  • TIAN, Feng
    Suzhou Jiangsu 215600 (CN)
  • WANG, Xintong
    Suzhou Jiangsu 215600 (CN)
  • ZHANG, Kailin
    Suzhou Jiangsu 215600 (CN)
  • HU, Zhihao
    Castro Valley CA 94546 (US)

(74) Representative: Kurig, Thomas 
Becker Kurig & Partner Patentanwälte mbB Bavariastraße 7
80336 München
80336 München (DE)


(56) References cited: : 
CN-A- 102 605 025
CN-A- 105 463 042
 CN-A- 104 774 799
   
  • YINGMIAO: "Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module", Appl Microbiol Biotechnol, vol. 101, no. 4 13 October 2016 (2016-10-13), pages 1409-1417, XP036137870, ISSN: 1432-0614 Retrieved from the Internet: URL:doi: 10.1007/s00253-016-7874-0
  • KAKEHI M ET AL: "Complete deficiency of 5'-nucleotidase activity in Escherichia coli leads to loss of growth on purine nucleotides but not of their excretion", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, KARGER, CH, vol. 13, no. 1-3, 1 August 2007 (2007-08-01), pages 96-104, XP008103067, ISSN: 1464-1801, DOI: 10.1159/000103601
  • BULAWA C E ET AL: "ISOLATION AND CHARACTERIZATION OF ESCHERICHIA-COLI STRAINS DEFECTIVE IN CDP-DIGLYCERIDE HYDROLASE", JOURNAL OF BIOLOGICAL CHEMISTRY.(MICROFILMS), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 259, no. 18, 25 September 1984 (1984-09-25), pages 11257-11264, XP002272208,
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).