(19)

(11)

EP 3 654 996 A1

(12)

(43) Date of publication: 27.05.2020 Bulletin 2020/22 (21) Application number: 18836082.0 (22) Date of filing: 20.07.2018

(51) International Patent Classification (IPC):  A61K 35/39(2015.01) A61K 9/50(2006.01) A61K 35/545(2015.01) (86) International application number: PCT/US2018/043179 (87) International publication number: WO 2019/018818 (24.01.2019 Gazette 2019/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.07.2017 US 201762535659 P (71) Applicant: Semma Therapeutics, Inc. Cambridge, Massachusetts 02142 (US)	(72) Inventors: POH, Yeh-Chuin Belmont, Massachusetts 02478 (US) HARB, George Boston, Massachusetts 02125 (US) PAGLIUCA, Felicia J. Boston, Massachusetts 02116 (US) (74) Representative: J A Kemp LLP  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)