(19)

(11)

EP 3 658 162 A1

(12)

(43) Date of publication: 03.06.2020 Bulletin 2020/23 (21) Application number: 18839425.8 (22) Date of filing: 24.07.2018

(51) International Patent Classification (IPC):  A61K 35/12(2015.01) A61K 48/00(2006.01) A61K 35/39(2015.01) (86) International application number: PCT/US2018/043539 (87) International publication number: WO 2019/023266 (31.01.2019 Gazette 2019/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 25.07.2017 US 201762536535 P (71) Applicants: Purdue Research Foundation West Lafayette, IN 47906 (US) Voytik-Harbin, Sherry L. West Lafayette, Indiana 47906 (US) Stephens, Clarissa Hernandez West Lafayette, Indiana 47906 (US)

(72) Inventors: VOYTIK-HARBIN, Sherry L. West Lafayette, Indiana 47906 (US) STEPHENS, Clarissa Hernandez West Lafayette, Indiana 47906 (US) (74) Representative: Zwicker, Jörk  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)