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EP 3 658 548 A1

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(43) Date of publication: 03.06.2020 Bulletin 2020/23 (21) Application number: 18756023.0 (22) Date of filing: 27.07.2018

(51) International Patent Classification (IPC):  C07D 403/12(2006.01) C07C 255/47(2006.01) C07D 231/14(2006.01) C07D 237/24(2006.01) C07D 411/12(2006.01) C07D 417/12(2006.01) C07D 207/16(2006.01) C07D 401/14(2006.01) C07D 213/82(2006.01) C07D 401/12(2006.01) C07D 239/42(2006.01) C07D 411/14(2006.01) C07D 417/14(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2018/044051 (87) International publication number: WO 2019/023553 (31.01.2019 Gazette 2019/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.07.2017 US 201715663273 (71) Applicant: Arvinas Operations, Inc. New Haven, CT 06511 (US)

(72) Inventors: CREW, Andrew P. Guilford Connecticut 06437 (US) BERLIN, Michael Flemington New Jersey 08822 (US) CHEN, Xin Trumbull Connecticut 06611 (US) CREWS, Craig M. New Haven Connecticut 06511 (US) DONG, Hanqing Madison Connecticut 06443 (US) QIAN, Yimin Plainsboro New Jersey 08536 (US) SNYDER, Lawrence Killingworth Connecticut 06419 (US) WANG, Jing Milford Connecticut 06460 (US) ZIMMERMANN, Kurt Durham Connecticut 06422 (US) (74) Representative: Kasche & Partner  Resirain 1 8125 Zollikerberg/Zürich 8125 Zollikerberg/Zürich (CH)