(19)

(11)

EP 3 661 497 A1

(12)

(43) Date of publication: 10.06.2020 Bulletin 2020/24 (21) Application number: 18928207.2 (22) Date of filing: 02.08.2018

(51) International Patent Classification (IPC):  A61K 31/365(2006.01) A61K 47/34(2017.01) C08G 63/78(2006.01) A61K 47/30(2006.01) C08G 63/00(2006.01) C08G 63/82(2006.01) (86) International application number: PCT/US2018/045013 (87) International publication number: WO 2020/027845 (06.02.2020 Gazette 2020/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.08.2017 US 201762540672 P (71) Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION Fort Collins, CO 80522 (US) Chen, Eugene Y. Fort Collins, Colorado 80526 (US) Zhu, Jian-Bo Fort Collins, Colorado 80526 (US)

(72) Inventors: CHEN, Eugene Y. Fort Collins, Colorado 80526 (US) ZHU, Jian-Bo Fort Collins, Colorado 80526 (US) (74) Representative: FRKelly  27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE)