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EP 3 661 551 A1

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(43) Date of publication: 10.06.2020 Bulletin 2020/24 (21) Application number: 18750578.9 (22) Date of filing: 03.08.2018

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61P 1/00(2006.01) C07K 16/28(2006.01) (86) International application number: PCT/US2018/045195 (87) International publication number: WO 2019/028367 (07.02.2019 Gazette 2019/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.08.2017 US 201762541242 P 21.09.2017 US 201762561593 P 08.03.2018 EP 18305252 (71) Applicants: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591-6707 (US) Sanofi Biotechnology 75008 Paris (FR)

(72) Inventors: RADIN, Allen Tarrytown, New York 10591 (US) HAMILTON, Jennifer D. Tarrytown, New York 10591 (US) MANNENT, Leda Paris 75008 (FR) (74) Representative: J A Kemp LLP  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)