(19)
(11) EP 3 662 407 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
25.06.2025 Bulletin 2025/26

(45) Mention of the grant of the patent:
07.05.2025 Bulletin 2025/19

(21) Application number: 18759763.8

(22) Date of filing: 02.08.2018
(51) International Patent Classification (IPC): 
G06T 7/00(2017.01)
G06T 7/194(2017.01)
G06V 20/69(2022.01)
 G06T 7/143(2017.01)
G06V 10/50(2022.01)
G06T 7/11(2017.01)
(52) Cooperative Patent Classification (CPC):
G06T 7/11; G06T 7/143; G06T 7/194; G06T 7/0012; G06V 20/69; G06V 10/50
(86) International application number:
PCT/IL2018/050862
(87) International publication number:
WO 2019/026081 (07.02.2019 Gazette 2019/06)

(54)

SYSTEMS AND METHODS FOR ANALYSIS OF TISSUE IMAGES

SYSTEME UND VERFAHREN ZUR ANALYSE VON GEWEBEBILDERN

SYSTÈMES ET PROCÉDÉS D'ANALYSE D'IMAGES DE TISSU

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 03.08.2017 US 201762540652 P

(43) Date of publication of application:
10.06.2020 Bulletin 2020/24

(73) Proprietor: NUCLEAI LTD
Tel Aviv - Jaffa (IL)

(72) Inventors:
  • VEIDMAN, Avi
    7051603 Gedera (IL)
  • CHOREV, Lotan
    6998516 Tel-Aviv (IL)

(74) Representative: Borsano, Corrado et al
Metroconsult S.r.l. Foro Buonaparte, 51
20121 Milano
20121 Milano (IT)


(56) References cited: : 
WO-A1-2016/075096
WO-A1-2016/087592
WO-A1-2016/154116
US-A1- 2008 082 468
US-A1- 2008 273 788
 WO-A1-2016/075096
WO-A1-2016/087592
WO-A1-2016/154116
US-A1- 2008 082 468
US-A1- 2008 273 788
   
  • KONG BIN ET AL: "Cancer Metastasis Detection via Spatially Structured Deep Network", 23 May 2017, ADVANCES IN BIOMETRICS : INTERNATIONAL CONFERENCE, ICB 2007, SEOUL, KOREA, AUGUST 27 - 29, 2007 ; PROCEEDINGS; [LECTURE NOTES IN COMPUTER SCIENCE; LECT.NOTES COMPUTER], SPRINGER, BERLIN, HEIDELBERG, PAGE(S) 236 - 248, ISBN: 978-3-540-74549-5, XP047416155
  • LE HOU ET AL: "Patch-Based Convolutional Neural Network for Whole Slide Tissue Image Classification", 9 March 2016 (2016-03-09), XP055523985, Retrieved from the Internet <URL:https://arxiv.org/pdf/1504.07947.pdf> [retrieved on 20181114]
  • BAUTISTA P A ET AL: "Digital staining for histopathology multispectral images by the combined application of spectral enhancement and spectral transformation", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY,EMBC, 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, IEEE, 30 August 2011 (2011-08-30), pages 8013 - 8016, XP032320540, ISBN: 978-1-4244-4121-1, DOI: 10.1109/IEMBS.2011.6091976
  • DAYONG WANG ET AL: "Deep Learning for Identifying Metastatic Breast Cancer", 18 June 2016 (2016-06-18), XP055568296, Retrieved from the Internet <URL:https://arxiv.org/pdf/1606.05718.pdf> [retrieved on 20190315]
  • S. ISSAC NIWAS ET AL: "An Expert Support System for Breast Cancer Diagnosis using Color Wavelet Features", JOURNAL OF MEDICAL SYSTEMS, vol. 36, no. 5, 18 October 2011 (2011-10-18), New York, pages 3091 - 3102, XP055569508, ISSN: 0148-5598, DOI: 10.1007/s10916-011-9788-9
  • VITORINO RAMOS ET AL: "Image Colour Segmentation by Genetic Algorithms", 17 December 2004 (2004-12-17), XP055569512, Retrieved from the Internet <URL:https://arxiv.org/ftp/cs/papers/0412/0412087.pdf> [retrieved on 20190315]
  • MONIKA SINHA ET AL: "IMPROVED BRAIN TUMOR DETECTION WITH ONTOLOGY", 2 March 2012 (2012-03-02), XP055569532, Retrieved from the Internet <URL:https://pdfs.semanticscholar.org/3149/3d4ef50fb3ff6fd799687ad5fd2115e208f1.pdf> [retrieved on 20190314]
  • KONG BIN ET AL: "Cancer Metastasis Detection via Spatially Structured Deep Network", 23 May 2017, INTERNATIONAL CONFERENCE ON SIMULATION, MODELING, AND PROGRAMMING FOR AUTONOMOUS ROBOTS,SIMPAR 2010; [LECTURE NOTES IN COMPUTER SCIENCE; LECT.NOTES COMPUTER], SPRINGER, BERLIN, HEIDELBERG, PAGE(S) 236 - 248, ISBN: 978-3-642-17318-9, XP047416155
  • LE HOU ET AL: "Patch-Based Convolutional Neural Network for Whole Slide Tissue Image Classification", 9 March 2016 (2016-03-09), XP055523985, Retrieved from the Internet <URL:https://arxiv.org/pdf/1504.07947.pdf> [retrieved on 20181114]
  • BAUTISTA P A ET AL: "Digital staining for histopathology multispectral images by the combined application of spectral enhancement and spectral transformation", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY,EMBC, 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, IEEE, 30 August 2011 (2011-08-30), pages 8013 - 8016, XP032320540, ISBN: 978-1-4244-4121-1, DOI: 10.1109/IEMBS.2011.6091976
  • DAYONG WANG ET AL: "Deep Learning for Identifying Metastatic Breast Cancer", 18 June 2016 (2016-06-18), XP055568296, Retrieved from the Internet <URL:https://arxiv.org/pdf/1606.05718.pdf> [retrieved on 20190314]
  • S. ISSAC NIWAS ET AL: "An Expert Support System for Breast Cancer Diagnosis using Color Wavelet Features", JOURNAL OF MEDICAL SYSTEMS., vol. 36, no. 5, 18 October 2011 (2011-10-18), NY, USA, pages 3091 - 3102, XP055569508, ISSN: 0148-5598, DOI: 10.1007/s10916-011-9788-9
  • VITORINO RAMOS ET AL: "Image Colour Segmentation by Genetic Algorithms", 17 December 2004 (2004-12-17), XP055569512, Retrieved from the Internet <URL:https://arxiv.org/ftp/cs/papers/0412/0412087.pdf> [retrieved on 20190314]
  • MONIKA SINHA ET AL: "IMPROVED BRAIN TUMOR DETECTION WITH ONTOLOGY", 2 March 2012 (2012-03-02), XP055569532, Retrieved from the Internet <URL:https://pdfs.semanticscholar.org/3149/3d4ef50fb3ff6fd799687ad5fd2115e208f1.pdf> [retrieved on 20190314]
   
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