| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
18.08.2017 US 201762547220 P
28.12.2017 US 201762611166 P
|
| (43) |
Date of publication of application: |
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24.06.2020 Bulletin 2020/26 |
| (60) |
Divisional application: |
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24205258.7 |
| (73) |
Proprietor: Neutrolis, Inc. |
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Cambridge, MA 02142 (US) |
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| (72) |
Inventors: |
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- FUCHS, Tobias A.
Cambridge, MA 02139 (US)
- JIMÉNEZ-ALCÁZAR, Miguel
Cambridge, MA 02139 (US)
- GÖBEL, Josephine (formerly BITTERLING, Josephine)
Cambridge, MA 02139 (US)
- ENGLERT, Hanna
Cambridge, MA 02139 (US)
|
| (74) |
Representative: Grund, Martin et al |
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Grund Intellectual Property Group
Patentanwälte und Solicitor PartG mbB
Steinsdorfstraße 2
80538 München
80538 München (DE) |
| (56) |
References cited: :
WO-A2-2011/053982
US-A1- 2016 376 366
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US-A1- 2009 010 966
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|
- ANDREW WILBER ET AL: "Deoxyribonuclease 1-like III is an inducible macrophage barrier
to liposomal transfection", MOLECULAR THERAPY, NO LONGER PUBLISHED BY ELSEVIER, vol.
6, no. 1, 1 July 2002 (2002-07-01), pages 35 - 42, XP002641392, ISSN: 1525-0016, DOI:
10.1006/MTHE.2002.0625
- JIMÉNEZ-ALCÁZAR M ET AL: "Impaired DNase1-mediated degradation of neutrophil extracellular
traps is associated with acute thrombotic microangiopathies", JOURNAL OF THROMBOSIS
AND HAEMOSTASIS, vol. 13, no. 5, 13 April 2015 (2015-04-13), pages 732 - 742, XP055782172,
Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/25418346> DOI:
10.1111/jth.12796
- SISIRAK VANJA ET AL: "Digestion of Chromatin in Apoptotic Cell Microparticles Prevents
Autoimmunity", CELL, ELSEVIER, AMSTERDAM NL, vol. 166, no. 1, 9 June 2016 (2016-06-09),
pages 88 - 101, XP029627879, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2016.05.034
- SHIOKAWA DAISUKE ET AL: "Identification of two functional nuclear localization signals
in DNase [gamma] and their roles in its apoptotic DNase activity", BIOCHEMICAL JOURNAL,
vol. 376, no. 2, 1 December 2003 (2003-12-01), pages 377 - 381, XP055782937, ISSN:
0264-6021, Retrieved from the Internet <URL:http://portlandpress.com/biochemj/article-pdf/376/2/377/712183/bj3760377.pdf>
DOI: 10.1042/bj20030820
- JIMÉNEZ-ALCÁZAR MIGUEL ET AL: "Host DNases prevent vascular occlusion by neutrophil
extracellular traps", SCIENCE, vol. 358, no. 6367, 1 December 2017 (2017-12-01), US,
pages 1202 - 1206, XP055783049, ISSN: 0036-8075, DOI: 10.1126/science.aam8897
- MONA SAFFARZADEH ET AL: "Fighting against the dark side of neutrophil extracellular
traps in disease : manoeuvres for host protection", CURRENT OPINION IN HEMATOLOGY,
vol. 20, no. 1, 1 January 2013 (2013-01-01), US, pages 3 - 9, XP055471240, ISSN: 1065-6251,
DOI: 10.1097/MOH.0b013e32835a0025
- JORCH SELINA K ET AL: "An emerging role for neutrophil extracellular traps in noninfectious
disease", NATURE MEDICINE, vol. 23, no. 3, 1 March 2017 (2017-03-01), New York, pages
279 - 287, XP055785209, ISSN: 1078-8956, Retrieved from the Internet <URL:http://www.nature.com/articles/nm.4294>
DOI: 10.1038/nm.4294
- DABROWSKA D ET AL: "New Aspects of the Biology of Neutrophil Extracellular Traps.",
SCANDINAVIAN JOURNAL OF IMMUNOLOGY DEC 2016, vol. 84, no. 6, December 2016 (2016-12-01),
pages 317 - 322, ISSN: 1365-3083
- BRINKMANN VOLKER ET AL: "Neutrophil extracellular traps kill bacteria", SCIENCE, AMERICAN
ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 303, no. 5663, 5 March 2004 (2004-03-05),
pages 1532 - 1535, XP002469080, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1092385
- KOBAYASHI, Y ET AL.: "Synchronous growth of Pichia Pastoris for a high rate production
of Dnasel ata microquantities", THE 10TH APCCHE CONGRESS THE ASIAN PACIFIC CONFEDERATION
OF CHEMICAL ENGINEERING : CONFERENCE PROCEEDINGS : OCTOBER 17-21, 2004 KITAKYUSHU,
JAPAN, no. 833, 1 January 2004 (2004-01-01), pages 1 - 6, XP055679026, DOI: 10.11491/apcche.2004.0.953.0
- HAKKIM, ABDUL ET AL.: "Impairment of neutrophil extracellular trap degradation is
associated with lupus nephritis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES
, vol. 107, no. 21, May 2010 (2010-05-01), pages 9813 - 9818, XP0002592735, DOI: 10.1073/pnas0909927107
- PICCOLO, F ET AL.: "Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease
for Pleural Infection. An Effective and Safe Alternative to Surgery", ANNALS ATS,
vol. 11, no. 9, November 2014 (2014-11-01), pages 1419 - 1425, XP055678828, DOI: 10.1513/AnnalsATS.201407-329OC
- PERINI ET AL: "Topical application of Acheflan on rat skin injury accelerates wound
healing: a histopathological, immunohistochemical and biochemical study", BMC COMPLEMENTARY
MEDICINE AND THERAPIES, vol. 15, 203, 30 June 2015 (2015-06-30), XP055678836, DOI:
10.1186/s12906-015-0745x
- ANDREW WILBUR ET AL: "Deoxyribonuclease I-like III Is an Inducible Macrophage Barrier
to Liposomal Transfection", MOLECULAR THERAPY, vol. 6, no. 1, 2002, pages 35 - 42,
XP002641392, DOI: 10.1006/mthe.2002.0625
- BERNTSSON RP. ET AL.: "Structural insight into DNA binding and oligomerization of
the multifunctional Cox protein of bacteriophage P2.", NUCLEIC ACIDS RESEARCH, vol.
42, no. 4, 23 November 2013 (2013-11-23), pages 2725 - 2735, XP055678852, DOI: 10.1093/nar/gkt1119
|
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