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(11)

EP 3 675 766 A1

(12)

(43) Date of publication: 08.07.2020 Bulletin 2020/28 (21) Application number: 18851915.1 (22) Date of filing: 27.08.2018

(51) International Patent Classification (IPC):  A61B 90/10(2016.01) A61B 17/00(2006.01) A61B 90/14(2016.01) A61B 5/03(2006.01) A61B 34/20(2016.01) A61B 90/40(2016.01) (86) International application number: PCT/US2018/048068 (87) International publication number: WO 2019/046153 (07.03.2019 Gazette 2019/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.08.2017 US 201762550764 P (71) Applicant: The Penn State Research Foundation University Park, PA 16802 (US)	(72) Inventors: HAZARD III, Sprague, W. Hummelstown, PA 17036 (US) FELL, Barry Hummelstown, PA 17036 (US) HALUCK, Randy Lititz, PA 17543 (US) ROHATGI, Pratik Hummelstown, PA 17036 (US) DILLON, Peter Harrisburg, PA 17111 (US) (74) Representative: Leonard, Thomas Charles et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)