(19)
(11) EP 3 681 989 A1

(12)

(43) Date of publication:
22.07.2020 Bulletin 2020/30

(21) Application number: 18779985.3

(22) Date of filing: 14.09.2018
(51) International Patent Classification (IPC): 
C12M 1/00(2006.01)
C12M 1/34(2006.01)
(86) International application number:
PCT/US2018/051100
(87) International publication number:
WO 2019/055796 (21.03.2019 Gazette 2019/12)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 15.09.2017 US 201762559142 P

(71) Applicant: Bristol-Myers Squibb Company
Princeton, NJ 08543 (US)

(72) Inventors:
  • ERLANDSON, Timothy C.
    Berlin Massachusetts 01503 (US)
  • YEE, Joon Chong
    Acton Massachusetts 01720 (US)
  • RAY, Sarbajita
    Boxborough Massachusetts 01719 (US)
  • BORYS, Michael Christopher
    Groton Massachusetts 01450 (US)
  • HILL, Charles Anthony
    Groton Massachusetts 01450 (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) ONLINE BIOMASS CAPACITANCE MONITORING DURING LARGE SCALE PRODUCTION OF POLYPEPTIDES OF INTEREST