(19)

(11)

EP 3 684 336 A1

(12)

(43) Date of publication: 29.07.2020 Bulletin 2020/31 (21) Application number: 18859166.3 (22) Date of filing: 21.09.2018

(51) International Patent Classification (IPC):  A61K 9/127(2006.01) A61Q 19/00(2006.01) A61K 35/28(2015.01) C07K 14/78(2006.01) (86) International application number: PCT/US2018/052213 (87) International publication number: WO 2019/060719 (28.03.2019 Gazette 2019/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.09.2017 US 201715712294 (71) Applicant: University of Miami Miami, Florida 33136 (US)	(72) Inventor: BADIAVAS, Evangelos, V. Coral Gables FL 33136 (US) (74) Representative: Icosa  83 avenue Denfert-Rochereau 75014 Paris 75014 Paris (FR)