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EP 3 684 424 A1

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(43) Date of publication: 29.07.2020 Bulletin 2020/31 (21) Application number: 18859613.4 (22) Date of filing: 11.09.2018

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61K 39/00(2006.01) C12N 5/16(2006.01) C07H 21/04(2006.01) C12N 5/071(2010.01) C12N 15/00(2006.01) C07K 16/00(2006.01) (86) International application number: PCT/US2018/050417 (87) International publication number: WO 2019/060174 (28.03.2019 Gazette 2019/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.09.2017 US 201762561815 P 11.12.2017 US 201762597128 P 08.03.2018 US 201862640153 P 03.05.2018 US 201862666381 P 03.05.2018 US 201862666385 P (71) Applicant: H. Lee Moffitt Cancer Center And Research Institute, Inc. Tampa, FL 33612 (US)

(72) Inventor: DAVILLA, Marco L. Tampa, Florida 33606 (US) (74) Representative: Moré, Solveig Helga et al Kroher Strobel Rechts- und Patentanwälte PartmbB Bavariaring 20 80336 München 80336 München (DE)