(19)

(11)

EP 3 694 512 A1

(12)

(43) Date of publication: 19.08.2020 Bulletin 2020/34 (21) Application number: 17788070.5 (22) Date of filing: 12.10.2017

(51) International Patent Classification (IPC):  A61K 31/454(2006.01) A61K 31/7056(2006.01) A61P 31/12(2006.01) A61K 31/498(2006.01) A61K 31/7072(2006.01) (86) International application number: PCT/US2017/056298 (87) International publication number: WO 2019/074507 (18.04.2019 Gazette 2019/16)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (71) Applicant: Abbvie Inc. North Chicago, IL 60064 (US)

(72) Inventors: AWNI, Walid M. Green Oaks, Illinois 60048 (US) BERNSTEIN, Barry M. Mequon, Wisconsin 53092 (US) CAMPBELL, Andrew L. Lake Forest, Illinois 60045 (US) DUTTA, Sandeep Lincolnshire, Illinois 60069 (US) LIN, Chih-Wei Vernon Hills, Illinois 60061 (US) LIU, Wei Mundelein, Illinois 60060 (US) PILOT-MATIAS, Tami Green Oaks, Illinois 60048 (US) MENON, Rajeev M. Buffalo Grove, Illinois 60089 (US) MENSING, Sven 68001 Mannheim (DE) PODSADECKI, Thomas J. Chicago, Illinois 60654 (US) RODRIGUES JUNIOR, Lino Chicago, Illinois 60660 (US) SAMANTI, Suvajit North Chicago, Illinois 60064 (US) TRINH, Roger Chicago, Illinois 60640 (US) WANG, Tianli Lake Bluff, Illinois 60044 (US) YAO, Betty B. Libertyville, Illinois 60048 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)